A review of lignans from genus Kadsura and their spectrum characteristics
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摘要:
Abstract:
Kadsura belongs to the Schisandroideae subfamily of Magnoliaceae. Plants from genus Kadsura are widely distributed in the South and Southwest of China. The plants of the genus are widely used as folk medicine for a long time in history, with the functions of relieving pain, promoting 'qi' circulation, activating blood resolve stasis, and applications in the treatment of rheumatoid arthritis and gastroenteric disorders. Lignans are the primary characteristic constituents with various biological activities of plants from genus Kadsura. This paper summarized 81 lignans isolated from the plants of genus Kadsura over the past eight years (from 2014 to 2021)，which belong to five types: dibenzocyclooctadienes, spirobenzofuranoid dibenzocyclooctadienes, aryltetralins, diarylbutanes and tetrahydrofurans. Each type of these lignans possess typical characteristics in proton magnetic resonance (1H-NMR) and carbon-13 nuclear magnetic resonance (13C-NMR) spectra, the NMR regularities of these types of lingans were summarized, which provided a useful reference for the structural analysis of lignans. The relationships between lignans and pharmacodynamics were also systematically analyzed, the lignans were predicted to be the quality markers (Q-marker) of Kadsura genus.
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This study was financially supported by the National Natural Science Foundation of China (No. 81703819, 81874369 and 82074122), and Natural Science Foundation of Hunan Province (No. 2020JJ4463 and 2020JJ4064).
Liu Zhanga, Yan-zhe Jiaa, Bin Lia, Cai-yun Penga, Yu-pei Yanga, Wei Wanga, Chang-xiao Liub. A review of lignans from genus Kadsura and their spectrum characteristics[J]. Chinese Herbal Medicines (CHM),2021,13(2):157-166
