Pharmacokinetic studies of multi-bioactive components in rat plasma after oral administration of Xintiantai I extract and effects of guide drug borneol on pharmacokinetics
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摘要:
Abstract:
Objective: To investigate the in vivo pharmacokinetic characteristics of 17 bioactive components includ- ing ginsenoside Rg1, Rb1, Rd, berberine, epiberberine, jatrorrhizine, palmatine, columbamine, coptisine, evodiamine, dehydroevodiamine, rutaecarpine, limonin, hyperin, curcumin, demethoxycurcumin and bis- demethoxycurcumin in rat plasma after oral administration of Xintiantai I extract powder (XI) and Xin- tiantai I without guide drug borneol extract powder (XI without borneol), and study the compatibility effects of guide drug borneol on the pharmacokinetics. Methods: A UHPLC-MS/MS method was established and fully validated for the comparative pharmacoki- netics of 17 bioactive components. The pharmacokinetics parameters of 17 bioactive components after oral administration of XI and XI without borneol were calculated by the software of DAS 3.0 and inter- compared. Results: The specificity, linearity, lower limit of quantification (LLOQ), precision, accuracy, extraction re- covery rates, matrix effects, and stability of the UHPLC-MS/MS assay were good within the acceptance criteria from FDA guidelines. Guide drug borneol can significantly increase AUC of G-Rd, palmatine, hy- perin, curcumin, demethoxycurcumin, bisdemethoxycurcumin and C max of 16 bioactive components ex- cept for dehydroevodiamine (P < 0.05), decrease T max of G-Rd, berberine, columbamin, coptisine, limonin and MRT of 17 bioactive components in XI group (P < 0.05). Conclusion: Guide drug borneol enhanced the absorption of G-Rd, palmatine, hyperin, curcumin, demethoxycurcumin and bisdemethoxycurcumin.
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This work was supported by the National Natural Science Foundation of China (No. 81603669), Guangdong Science and Technology Department Public Welfare Research Project (grant number 2015B020211001), Natural Science Foundation of Guang- dong Province (No. 2017A030313747, 2018A030313995), Science and Technology Project of Shenzhen (No. JCYJ20160428105555220, JCYJ20180227175929767) and Shenzhen Health and Family Plan- ning System Research Project (No. 201601052).
Shao-yu Liang a, b, Yong-chang Zeng a, b, Qian-qian Jiang a, b, Jun-hong Wu a, b, Zheng-zhi Wu a, b. Pharmacokinetic studies of multi-bioactive components in rat plasma after oral administration of Xintiantai I extract and effects of guide drug borneol on pharmacokinetics[J]. Chinese Herbal Medicines (CHM),2020,12(1):79-87
