Objective: To study the coumarin from the seeds oil leavings of Xanthoceras Sorbifolia. Methods: The chemical constituents were isolated and purified by combination of silica gel, macroporous resin, Sephadex LH-20, and ODS column chromatography. Their structures were elucidated by spectral and chemical methods. The cytotoxicity of the new compound against ten selected human cancer cell lines was assayed. Results: Five comarins were isolated and identified as fraxetin-7-O-β-D-[6'-(3''-hydroxyl-3''- methylglutaryl)] glucopyranoside (1), fraxoside (2), fraxetin (3), scopoline (4), and esculetin (5), respectively. Conclusion: Compound 1 is a new compound. Unfortunately, this compound exhibited no cytotoxicity with tested cell lines.
关键词:
香豆素;细胞毒活性;秦皮素;秦皮苷;文冠果
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Project Supported:
This research was financially supported by the Natural Science Foundation of Liaoning Province (No.2015020720), Teaching Reform Project of Jinzhou Medical University (No.YA2016044) and Student Innovation Training Program of Jinzhou Medical University (No.201710160000082).
Hong-jin Zhu a, Li-li Yu a, Jia-chuan Liu a, Mei-yu Wang a, Tong Zhang a, Feng Qiu b. A new coumarin glucoside ester from seeds oil leavings of Xanthoceras sorbifolia[J]. Chinese Herbal Medicines (CHM),2019,11(1):113-115
