Objective: Sepsis, a systemic response to infection, often leads to end-organ dysfunction. Despite its high rates of mortality and morbidity, its pathophysiology is still poorly understood. Coptidis Rhizoma and its main active alkaloid compound, berberine, have been as anti-bacterial and anti-inflammatory drugs used in clinic. The objective of this study was to gain more insights towards understanding the sepsis associated with drug absorption and disposition and treatments of berberine and Coptidis Rhizoma dynamically. Methods: Pharmacokinetic and metabolomic studies of Coptidis Rhizoma and its main active component berberine have been performed. Results: Cecal ligation and puncture (CLP) induced sepsis showed marked changes of metabolites concerning energy metabolism and amino acids metabolisms, which could be reversed towards the normal state by Coptidis Rhizoma and berberine. Conclusion: Berberine exhibited an equivalent and even better therapeutic effect than Coptidis Rhizoma.
关键词:
小檗碱;盲肠结扎穿孔;黄连;代谢组学;脓毒症
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Project Supported:
This work was funded by the Key Project of National Natural Science Foundation of China (No. 81430092), the Program for Changjiang Scholars and Innovative Research Team in University (IRT_15R63), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).
Pei Li, Shan-ting Liao, Jun-Song Wang, Qian Zhang, Yan Lv, Ming-Hua Yang, Ling-Yi Kong. Pharmacokinetic and NMR metabolomics approach to evaluate therapeutic effect of berberine and Coptidis Rhizoma for sepsis[J]. Chinese Herbal Medicines (CHM),2019,11(1):28-38
