Zhi-qiang Wang,Jie Shen,Pei Li,Shuang-shuang Liu,Fan Yi,Hai-bo Liu,Fan-rong Wu,Chun-nian He,Fei-hu Chen,Pei-gen Xiao.[J].Chinese Herbal Medicines (CHM),2017,9(4):307-320
Research on Quality Markers of Moutan Cortex: Quality Evaluation and Quality Standards of Moutan Cortex
  
DOI:10.1016/S1674-6384(17)60110-2
中文关键词:  
英文关键词:Moutan Cortex  multi-component assay  network pharmacology  quality evaluation  quality marker
基金项目:
Author NameAffiliation
Zhi-qiang Wang 1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China 2. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China 3. School of Pharmacy, Anhui Medical University, Hefei 230032, China 
Jie Shen 1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China 2. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China 
Pei Li 1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China 2. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China 
Shuang-shuang Liu 1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China 2. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China 
Fan Yi 1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China 2. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China 
Hai-bo Liu 1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China 2. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China 
Fan-rong Wu School of Pharmacy, Anhui Medical University, Hefei 230032, China 
Chun-nian He 1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China 2. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China 
Fei-hu Chen School of Pharmacy, Anhui Medical University, Hefei 230032, China 
Pei-gen Xiao 1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China 2. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China 
Hits: 185
Download times: 
中文摘要:
      
英文摘要:
      Objective To identify the quality markers of Moutan Cortex (MC) and establish the quality evaluation methods for multi-component assay and fingerprinting of MC. Methods The chemical constituents in MC were identified by HPLC-QTOF-MS. UPLC was employed for the multi-component assay and fingerprinting of MC. Furthermore, text mining was carried out to review the biosynthesis pathways and pharmacological and pharmacokinetic studies related to MC, and in silico target fishing was conducted to construct compound-target networks for MC. Results Sixteen compounds were clearly identified in MC and their structures were confirmed through comparison with literature data. In addition, the biosynthetic pathways and component specificities of the identified compounds were summarized and confirmed by text mining. Pharmacological activities, including traditional usage and modern pharmacological studies were summarized. A total of 282 targets from Homo sapiens were fished for 13 compounds. In addition, pharmacokinetic studies of different compounds were synopsized. Finally, multi-component assay and fingerprint of MC were established. Conclusion Eight major components are selected as quality markers of MC, such as oxypaeoniflorin, apiopaeonoside, albiflorin, paeonolide, paeoniflorin, 1,2,3,4,6- penta-O-galloyl-β-D-glucose, mudanpioside C and paeonol. These eight quality markers are successfully applied to the quality evaluation of MC, and could be useful in improving the current quality standards of MC.
HTML  View Full Text  View/Add Comment  Download reader
Close
Total Numbers of Visitors 1144153
CopyRight: Tianjin Press of Chinese Herbal Medicines
Address:308# An-shan West Road,Nankai District,Tianjin 300193,China
Tel:+86-22-23006901 Fax::+86-22-23006821 E_mail:chm@tiprpress.com
津备案:津ICP备13000267号 互联网药品信息服务资格证书编号:(津)-非经营性-2015-0031