Rong Li,Yan-bing Niu,Zhi-ying Dou.[J].Chinese Herbal Medicines (CHM),2015,7():
Comparative Study for Pharmacological Action of Corydalis Rhizoma before and after Processing
英文关键词:Corydalis Rhizoma  pharmacological action  processing  Yanhusuo Decoction  Yuanhu Zhitong Tablet
Author NameAffiliation
Rong Li Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 
Yan-bing Niu Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 
Zhi-ying Dou Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 
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      Objective To clarify the rationality and to provide reasonable usage references of processed Corydalis Rhizoma (CR) in clinic by comparing respectively pharmacological actions including analgesic, anti-inflammation, antiplatelet aggregation and spasmolysis of Yuanhu Zhitong Tablet (YZT) and Yanhusuo Decoction (YD) constituted with raw CR (RCR) or processed CR (PCR). Method The hot-board, acetic-acid-induced twisting experiments and mouse auricular swelling model by injecting xylene in the abdomen of mouse were adopted to investigate the analgesic and anti-inflammatory effects of the four formulas on Kunming mice; The experiment of contractile activity on isolated rat intestine smooth muscle on Wistar rats was applied to observe the spasmolysis effect of the four formulas; The experiments of platelet aggregation induced by ADP or collagen on Wistar rats by turbidimetry method were used to observe the anti-platelet aggregation effect of the four formulas. Results Compared with RCR in two prescriptions, PCR displayed better analgesic effect (P < 0.05, 0.01), while there was no difference on anti-inflammatory effect; Inhibition of smooth muscle spasm of the two prescriptions was presented well, and the prescription YD with PCR was remarkable (P < 0.05, 0.01); Compared with the blank group, the two prescriptions showed outstanding effects on anti-platelet aggregation (P < 0.01), but no difference between RCR and PCR in two prescriptions. Conclusion PCR can improve the analgesic effect of prescription YZT and intensify the spasmolysis effect of prescription YD, which can be explained by the Chinese medicine processing regulation. Therefore, PCR is suggested to be chosen in YZT and YD to cure pain symptoms.
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