A Novel Bihomoflavanonol with an Unprecedented Skeleton from Pteridium aquilinum
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
摘要:
Abstract:
Objective To seek the flavonoids with the unique structure and to investigate the chemical ingredients in the flavonoid-rich plant—Pteridium aquilinum. Methods The 80% EthOH extract from the degreased powder of P. aquilinum was partitioned by petroleum ether, CHCl3, EtOAc, n-butanol, and water, respectively. The EtOAc fraction was sequentially subjected to silica gel column, repeated Sephadex LH-20 column, and preparative TLC to give a new compound. The antitumor activity of the novel flavonoid was primarily evaluated by MTT. Results Compound 1, a biflavonoid with the unique structure named as pteridium III with an unprecedented bihomoflavanonol skeleton, was isolated from P. aquilinum. Compound 1 showed the in vitro antitumor activity against lung cancer cell NCI-H46, melanoma cell A375, and glioma cell U-7MG corresponding to the IC50 values of 22.9, 106.7, and 1540.5 μmol/L, respectively. No inhibition on gastric carcinoma SGC-7901 and prostatic carcinoma PC-3 was observed in the experiment. Conclusion A rare bihomoflavononol derivative, pteridium III, is obtained from the plant, which could enrich our knowedge on the chemical structures of flavonoids and bioactive constituents in P. aquilinum.
关键词:
Keywords:
Project Supported:
Natural Science Foundation of Anhui Province (090413113); The Provincial-Level Natural Science Foundation of Anhui Education Department (KJ2009A165, KJ20108259, KJ2012A277); National Natural Science Foundation of China (81274021)
CHEN Nai-dong, CHEN Nai-fu, CHEN Cun-wu, ZHANG Li. A Novel Bihomoflavanonol with an Unprecedented Skeleton from Pteridium aquilinum[J]. Chinese Herbal Medicines (CHM),2013,5(2):96-100
