Anti-diabetic Activity of Zhenqing Recipe and Ligustri Lucidi Fructus in Type 2 Diabetic Rats
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Anti-diabetic Activity of Zhenqing Recipe and Ligustri Lucidi Fructus in Type 2 Diabetic Rats
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Abstract:
Objective To investigate the influence of Zhenqing Recipe (ZQR) and Ligustri Lucidi Fructus (LLF) on diabetic rats and its possible mechanism. Methods The model of type 2 diabetic rats was established by feeding a high-sucrose-high-fat diet and injecting a low dose of Streptozotocin in Wistar rats. The model rats were randomly divided into three groups: diabetic model, ZQR-treated, and LLF-treated groups for 8-weeks treatment. The normal Wistar rats were as a normal control group. Results The level of fasting blood glucose in ZQR and LLF groups was decreased compared with model group (P < 0.01, 0.05, respectively). Both ZQR and LLF markedly reduced serum triglycerides (P < 0.01, 0.05, respectively), and increased the insulin sensitivity index (P < 0.05). Histopathology revealed that ZQR and LLF reduced pancreatic damage. Immunohistochemistry evaluation showed that the percentage of insulin positive cells in pancreatic island was higher than model group (P < 0.01, 0.05, respectively).The mRNA and protein expression of SREBP-1c in pancreas were significantly decreased in ZQR and FLL group (P < 0.01). Conclusion ZQR has therapeutic effect on type 2 diabetes, it ameliorates the histopathological changes of pancreas, protects β cells, improves insulin resistance, and attenuates the expression of SREBP-1c. This study also provides the anti-diabetic evidence of FLL even its effects are weaker than ZQR.
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National Natural Science Foundation of China (30672730); Developing Research Program of Science and Technology Bureau of Wuhan (20046001047)
WEN Xiu-ying, XU Wen-guang, XIONG Ling, XU Ming-wang, LIU Hao, ZHANG Hong, LUO Qiong, NIAO Qiu-hong, LIU Li-fang. Anti-diabetic Activity of Zhenqing Recipe and Ligustri Lucidi Fructus in Type 2 Diabetic Rats[J]. Chinese Herbal Medicines (CHM),2011,3(1):47-53
