Objective To evaluate toxicity and safety of trans-resveratrol (t-RSV). Methods For assays of acute toxicity, genetic toxicity, and sub-chronic toxicity, Ames test, mice bone marrow erythrocyte micronucleus, and mice sperm abnormality were performed. Results In the acute oral toxicity tests, maximum tolerable dose (15 g/kg) in male and female Kunming mice showed no toxicological signs. For 90-d feeding of t-RSV at dosage range of 167–500 mg/(kg?d) in both male and female Sprague-Dawley rats, no noticeable toxicological effects were observed. Conclusion T-RSV has no acute toxicity and no genotoxicity, no harmful effects on the human body at the tested dosage range and thus resveratrol is safe for human consumption.
