Quantitative Metabolomics: Analysis on Active Components in Extracts from Kaki Folium
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摘要:
Abstract:
Objective In order to analyze the active components in the extracts from Kaki Folium (KF), quantitative metabolomics approach was adopted to investigate the number of active components existing among the different extracts and their variation. Methods LC-MS method was established for the quantitative determination of the active components taking the mixture with reference substance as tested sample. Results In terms of the number of active components and amount presented in the different tested samples of KF extracted by many types of solvents, variation was observed. But rutin, astragalin, and kaempferol were presented in all samples. Difference was found between the samples extracted from the products on market and from the raw materials of KF processed by polar solvents with different recipes, however, the three active components were found in all samples examined. Conclusion These results might be valuable as all information could be used for the optimization of raw materials extraction procedure to enhance the productivity.
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Project Supported:
National Basic Research Plan (973 Plan) Foundation of China (2010CB735602); National Innovation Plan for New Drugs (2011ZX09304-002)
DAI Li-peng, GU Yuan, YIN Ren-jie, LIU Chang-xiao, SI Duan-yun. Quantitative Metabolomics: Analysis on Active Components in Extracts from Kaki Folium[J]. Chinese Herbal Medicines (CHM),2012,4(4):276-281
