Volume 13,Issue 1,2021 Table of Contents

Chang-xiao Liu

2021, 13(1).

[Abstract](170) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
We are coming to the end of 2020. In 2020, we’ve seen our party, government, doctors, and scientists use TCM products and medical technology in the treatment of the COVID-19 disease, but in new year of 2021, we face a new variant of the disease that requires a new vigilance, we need good drugs and vaccines to control and therapy of COVID-19. For CHM, 2021 is the year we can develop and believe CHM better. We are going on the way to the combination with our loved ones in the CHM by the normal and scientific edition way. In new issue in 2021, CHM published and contributed four papers on the study of the CHM's quality evaluation. 1.Quality is life By always remembering "Quality is life" of all of brands, we should invent innovated and striking strategies to meet the requirements of any medicinal products. Now, we are qualified to provide higher quality of medicinal products with efficiency and safety. We believe quality is the life of enterprise, the more pursues integrity, pragmatic and efficient operation of this, adhere to the cast quality brand, service in promoting the medical brand. One is primarily around the management of architectural changes across the life cycle, and another of course is managing this issue of quality across the all life cycle in the process of research, development, production and application. Our study is always remembering "Quality?is?life” in?innovated?methods, technologies, tools to?meet?the?requirements?of?clinical higher?efficiency and safety. 2. Quality study needs innovation Quality study is a system engineering, it needs new science theory, new techonology, new methods and tools. Such as chemometric smart tools are systematically analysis which will bring a profound effect on the ‘material basis and Q-markers’ exploration from TCMs. After data procession, the precise qualitative and quantitative results in chemical fingerprints and metabolic trajectories can ensure the reliability of “material basis and Q-markers" results (Chinese Herbal Medicines, 13(1), 4-18). Usually the data only obtained by chromatography-related technology cannot disclose the material basis or Q-markers in TCMs fully. The integration of multi-dimensional data can be clarified from multiple levels and multiple perspectives. With the development of chemometric tools, the drug properties/efficacy-related components and Q-markers will be more accurately for the internationalization and modernization of TCMs. Great challenges remain in optimizing the detection of herbal medicines and processing and mining data from the complex information obtained. An integrated strategy toward comprehensive characterization and quantification of multiple components was carried out in Gelsemium elegans (Chinese Herbal Medicines, 13(1), 19-38). This work contributed to the development of a powerful integrated strategy for chemical research based on liquid chromatography coupled with mass spectrometry (LC-MS) systems. Prof. Li’s team explored PAGE and HPTLC methods to evaluate Astragalus Radix from different germplasm resources (Chinese Herbal Medicines, 13(1), 39-50). In the research paper “A mathematical model for quality evaluation of total saponins of Panax japonicas based on hypolipidemic activity” (Chinese Herbal Medicines, 13(1), 51-56), authors performed the preliminarily explore for the establishment of a quality assessment method for total saponins of Panax japonicas associated with the hypolipidemic activity. All these attempts were with aim to make exploration for the innovation and standardization for TCM industy progress. Quality evaluation of TCM is one of important guarantees for safe drug use in clinical application. 3. Chinese Herbal Medicines contributed innovation development of TCM We always dedicated our great efforts and financial support to promote the development of journal, with view to providing an international communication platform for the up-to-date research achievements in the field of traditional Chinese Medicines. Chinese Herbal Medicines have published five research papers on TCM therapy of COVID-19 in special 2020 with lots of attention at home and abroad. We have successfully applied for China Science and Technology Journals Excellence Action Plan and been newly included in Scopus and DOAJ in 2020. In the 2021 New Year, CHM’s publishers sincerely thank to the experts of editorial board and all the authors, reviewers and readers for your loving and supporting. Let us work together to promote the innovative development of TCM.

2 How to identify â€˜Material basis - Quality markersâ€™ more accurately in Chinese herbal medicines from modern chromatography-mass spectrometry data-sets: Opportunities and challenges of chemometric tools

Min He , Yu Zhou

2021, 13(1). DOI: 10.1016/j.chmed.2020.05.006

[Abstract](678) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
Modern chromatography - mass spectrometer (MS) technology is an essential weapon in the exploration of traditional Chinese medicines (TCMs) which is based on the ‘effectiveness-material basis-quality markers (Q-markers)’. Nevertheless, the hardware bottleneck and irregular operation will limit the accuracy and comprehensiveness of test results. Chemometrics was thereby used to solve the existing problems: 1) The method of ‘design-modeling-optimization’ can be adopted to solve the multi-factor and multi-level problems in sample preparation/ parameter setting; 2) The approaches of signal processing can be used to calibrate the deviation from retention time (rt) dimension and mass-to-charge ratio (m/z) dimension in different types of instruments; 3) The methods of multivariate calibration and multivariate resolution can be utilized to analyze the co-eluting peaks in complex samples. When the researchers need to capture essential information on raw data sets extracting the higher level of information on essential features, 1) The significant components which affects the drug properties/efficacy can be find by the pattern recognition and variable selection; 2) Fingerprint-efficacy modeling is explored to clarify the material basis, or to screen out the Q-markers of biological significance; 3) Chemometric tools can apply to integrate chemical (metabolic) fingerprints with network pharmacology, bioinformatics, omics and others from a multi-level perspective. Under these programs, the qualitative/quantitative works will achieve in chemical (metabolic) fingerprint and metabolic trajectories, which leads to an accurate reflection of ‘material basis and Q-markers’ in TCMs. Likewise, an in-depth hidden information can be disclosed, so that the components of drug properties/efficacy will be found. More importantly, multidimensional data can be integrated with fingerprints to acquire more hidden information.

3 An integrated strategy toward comprehensive characterization and quantification of multiple components from herbal medicine: An application study in Gelsemium elegans

Meng-ting Zuoa , Yan-chun Liu a , Zhi-liang Suna , b , Li Lina , Qi Tangc , Pi Chengc , Zhao-ying Liu a , b , c

2021, 13(1). DOI: 10.1016/j.chmed.2020.06.002

[Abstract](694) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
Objective: To develop a powerful integrated strategy based on liquid chromatography coupled with mass spectrometry (LC-MS) systems for the comprehensive characterization and quantification of multiple components of herbal medicines. Methods: Firstly, different mobile phase additives, analysis time, and MS acquisition modes were orthogonally tested with liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (LC-QTOF/MS) in order to detect as many components of Gelsemium elegans as possible with high peak intensity. Secondly, several data mining strategies, including database searching, diagnostic ion filtering and neutral loss filtering, were utilized to perform chemical profiling. Subsequently, this study focused on the quantification and validation of the performance of a liquid chromatography-triple mass spectrometry (LC-QqQ/MS) assay based on derivative multiple reaction monitoring (DeMRM). Results: A total of 147 components from G. elegans were characterized, among them 116 nontarget components were reported for the first time. A sensitive and reproducible LC-QqQ/MS method was successfully developed and validated for the simultaneous relative quantification of 41 components of G. elegans. This LC-QqQ/MS method was then applied to compare the contents of components in the roots, stems and leaves. Conclusion: The present integrated strategy would significantly contribute to chemical studies on herbal medicine, and its utility could be extended to other research fields, such as metabolomics, quality control, and pharmacokinetics.

4 Identification and activity evaluation of Astragalus Radix from different germplasm resources based on specific oligosaccharide fragments

Shu-ying Li , Di Wangb , c , Xian-rong Lid , e , Xue-mei Qinb , Yu-guang Duf , Ke Lib , f

2021, 13(1). DOI: 10.1016/j.chmed.2020.07.004

[Abstract](595) [HTML](0) [PDF 0.00 Byte](0)

Abstract:

5 A mathematical model for quality evaluation of total saponins of Panax japonicas based on hypolipidemic activity

Dong-li Qia , c , Xiao-lin Yangb , Jing Chena , d , Fei Lia , Pei-pei Zhoua , Ping Chene , Li Yangb , Ru-feng Wangb

2021, 13(1). DOI: 10.1016/j.chmed.2020.04.004

[Abstract](593) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
Objective: The chemical finger printing-based methods for evaluating TCMs quality can report partial of TCMs quality without linking to effective constituents. In this study, a mathematical model was established for the quality evaluation of total saponins of Panax japonicus (TSPJ), a folk medicine in China and Japan for treating diseases, through coupling the dynamic changes of chemical constitutions with corresponding activities. Methods: High-performance liquid chromatography (HPLC) fingerprints were applied to establish the chromatographic database of TSPJ. The associated hypolipidemic activity database was determined by TG assay using HepG2 cell model. Correlation analyses of two databases were performed by partial least squares (PLS) for calculating regression coefficients, and the interval value of YZL value (the ratio of positive and negative peak-to-peak area coefficient) closely related to hypolipidemic activity was refined by the formula of Norminv function to value the quality of TSPJ. Results: In this study, the chromatographic data of 16 common peaks were obtained from 20 batches of TSPJ. After the estimate by this mathematical evaluation model, seven peaks were positively correlated with hypolipidemic activity, and nine peaks were negatively correlated with hypolipidemic activity. When the YZL value was less than 0.7861, the quality of sample was inferior, while YZL value was more than 6.6992, and the quality of samples was superior. The quality of another ten batches of TSPJ was further assessed to verify this method. Conclusion: These results indicated that the established model could be usefully applied to evaluate the quality of TSPJ in the hypolipidemic activity.

6 Flavonoids in myocardial ischemiaâ€“reperfusion injury: Therapeutic effects and mechanisms

Jun-ying Jiaa , Er-huan Zangb , Li-juan Lvc , Qin-yu Lib , Chun-hua Zhangb , Ying Xiad , Lei Zhange , Lian-sheng Dangf , Min-hui Lib , d , e , g

2021, 13(1). DOI: 10.1016/j.chmed.2020.09.002

[Abstract](352) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients’ quality of life and reduce mortality. However, reperfusion injury cannot be ignored. Flavonoids possess well-established antioxidant properties; They also have other benefits that may be relevant for ameliorating myocardial ischemia–reperfusion injury (MIRI). In this review, we focus on flavonoids with cardiovascular-protection function and emphasize their pharmacological effects. The main mechanisms of flavonoid pharmacological activities against MIRI involve the following aspects: a) antioxidant, b) anti-inflammatory, c) anti-platelet aggregation, d) anti-apoptosis, and e) myocardial-function regulation activities. We also summarized the effectiveness of flavonoids for MIRI.

7 Panax japonicus and chikusetsusaponins: A review of diverse biological acivities and pharmacology mechanism

Xiao-Juan Wanga , Qian Xie b , Yang Liub , Sai Jiangb , Wei Lib , Bin Lib , Wei Wangb , Chang-Xiao Liuc

2021, 13(1). DOI: 10.1016/j.chmed.2020.12.003

[Abstract](731) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
Panax japonicus, which in the Tujia dialect is known as “Baisan Qi” and “Zhujieshen”, is a classic “qi” drug of Tujia ethnomedicine and it has unique effects on disease caused by “qi” stagnation and blood stasis. This paper serves as the basis of further scientific research and development of Panax japonicus. The pharmacology effects of molecular pharmacology were discussed and summarized. P. japonicus plays an important role on several diseases, such as rheumatic arthritis, cancer, cardiovascular agents, and this review provides new insights into P. japonicus as promising agents to substitute ginseng and notoginseng.

8 Challenges and strategies in progress of drug delivery system for traditional Chinese medicine Salviae Miltiorrhizae Radix et Rhizoma (Danshen)

Ruo-ning Wanga , b , Hua-cong Zhao a , b , Jian-yu Huang a , b , Hong-lan Wang a , Jun-song Li a , b , Yin Lua , c , Liu-qing Di a , b

2021, 13(1). DOI: 10.1016/j.chmed.2020.08.001

[Abstract](504) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
Traditional Chinese medicines (TCMs), with a history of thousands of years, are widely used clinically with effective treatment. However, the drug delivery systems (DDSs) for TCMs remains major challenges due to the characteristics of multi-components including alkaloids, flavones, anthraquinones, glycosides, proteins, volatile oils and other types. Therefore, the novel preparations and technology of modern pharmaceutics is introduced to improve TCM therapeutic effects due to instability and low bioavailability of active ingredients. Salviae Miltiorrhizae Radix et Rhizoma, the radix and rhizomes of Salvia miltiorrhiza Bunge (Danshen in Chinese), is a well known Chinese herbal medicine for protecting the cardiovascular system, with active ingredients mainly including lipophilic tanshinones and hydrophilic salvianolic acids. In this review, this drug is taken as an example to present challenges and strategies in progress of DDSs for TCMs. This review would also summary the characteristics of active ingredients in it including physicochemical properties and pharmacological effects. The purpose of this review is to provide inspirations and ideas for the DDSs designed from TCMs by summarizing the advances on DDSs for both single- and multi-component from Danshen.

9 Advances in biotechnological production of santalenes and santalols

Wen-long Zhaa , b , Jia-chen Zia , b

2021, 13(1). DOI: 10.1016/j.chmed.2020.11.002

[Abstract](144) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
Sandalwood essential oil has been widely used not only as natural medicines but also in perfumery and food industries, with sesquiterpenoids as its major components including (Z)- α-santalol and (Z)-β-santalol and so on. The mature heartwoods of Santalum album, Santalum austrocaledonicum and Santalum spicatum are the major plant resources for extracting sandalwood essential oil, which have been overexploited. Synthetic biology approaches have been successfully applied to produce natural products on large scale. In this review, we summarize biosynthetic enzymes of santalenes and santalols, including various santalene synthases (STSs) and cytochrome P450 monooxygenases (CYPs), and then highlight the advances of biotechnological production of santalenes and santalols in heterologous hosts, especially metabolic engineering strategies for constructing santalene- and santalol-producing Saccharomyces cerevisiae.

10 Gene mining and efficient biosynthesis of a fungal peptidyl alkaloid

Chen Zhang , Bing-yu Liua , Jia-wang Liua , Dao-jiang Yana , Jian Baia , Ya-long Zhanga , Yan-hua Moub , You-cai Hua

2021, 13(1). DOI: 10.1016/j.chmed.2020.11.003

[Abstract](491) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
Objective: Peptidyl alkaloids, a series of important natural products can be assembled by fungal non-ribosomal peptide synthetases (NRPSs). However, many of the NRPSs associated gene clusters are silent under laboratory conditions, and the traditional chemical separation yields are low. In this study, we aim to discovery and efficiently prepare fungal peptidyl alkaloids assembled by fungal NRPSs. Methods: Bioinformatics analysis of gene cluster containing NRPSs from the genome of Penicillium thymicola, and heterologous expression of the putative gene cluster in Aspergillus nidulans were performed. Isolation, structural identification, and biological evaluation of the product from heterologous expression were carried out. Results: The putative tri-modular NRPS AncA was heterologous-expressed in A. nidulans to give anacine (1) with high yield, which showed moderate and selective cytotoxic activity against A549 cell line. Conclusion: Heterologous expression in A. nidulans is an efficient strategy for mining fungal peptidyl alkaloids.

11 Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson's model through apoptosis and iron accumulation inhibition

Xin Li a , Xiao-wen Jiang a , c , Hai-xiao Chu a , Qing-chun Zhao a , Huai-wei Ding b , Chao-hong Cai a

2021, 13(1). DOI: 10.1016/j.chmed.2020.12.004

[Abstract](428) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
Objective: Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in substantia nigra (SN). Our previous study demonstrated kukoamine A (KuA) to exhibit strong neuroprotective effects through antioxidative stress, and autophagy in MPTP/MPP+-induced PD models in vivo and in vitro. It is necessary to evaluate the efficacy of the anti-PD effects under various models. Methods: In the present study, total chemical synthesis was used to obtain KuA, which performed low content in Lycii Cortex. Then, 6-OHDA-induced PD model of PC12 cells was used to investigate the effects of KuA on PD. Results: Our results demonstrated that KuA ameliorated cell loss and mitochondrial membrane potential (MMP) loss, and inhibited Bax/Bcl-2 ratio increase that were induced by 6-OHDA. Iron accumulation in SN is thought to participate in neuronal death in PD, which subsequently resulted in oxidative stress and overexpression of α-synuclein caused by iron metabolism protein disorder. In our study, KuA could chelate cellular iron content and decrease iron influx. Moreover, KuA could upregulate the expression of ferroportin1 and Hephaestin, downregulate the expression of DMT1, TfR, and Ferritin to maintain cellular iron homeostasis avoiding neuronal death from cellular iron deposition. Moreover, KuA could decrease the expression of a-synuclein in cells. All the results indicated that KuA protected against neurotoxin-induced PD due to the apoptosis inhibition and iron homeostasis maintaining. Conlusion: KuA treatment might represent a neuroprotective treatment for PD.

12 Berberine exerts antidepressant-like effects via regulating miR-34a-synaptotagmin1/Bcl-2 axis

Li-tao Yi a , Ji-xiao Zhub , Shu-qi Donga , Min Chena , Cheng-fu Lic

2021, 13(1). DOI: 10.1016/j.chmed.2020.11.001

[Abstract](463) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
Objective: Berberine, a cationic alkaloid first isolated in 1917, has been approved by the China Drug Administration for decades. Accumulating evidence demonstrated its antidepressant-like activities in vivo. Our previous study has shown that chronic stress leads to the upregulation of miR-34a in the hippocampus of mice. This study aims to evaluate the underlying miR-34a mediated mechanism of berberine in chronic stress-induced depression in mice. Methods: In the present study, mice were administered with berberine during chronic stress. Levels of miR-34a, dendritic density, mitochondrial morphology, and neurogenesis were assessed in the hippocampus. Subsequently, miR-34a agomir was used as a pharmacological intervention for the investigation of berberine. Results: The results showed that berberine reversed the decrease in sucrose preference and the increase in latency to feed without altering total food consumption. Furthermore, chronic stress-induced overexpression of miR-34a decreased synaptotagmin-1 and Bcl-2 levels, thereby impairing spinal morphology, mitochondria and neurogenesis. Berberine inhibited miR-34a expression, in turn restored synaptotagmin-1 and Bcl-2 levels, and thus improved spinal morphology, mitochondria and neurogenesis in the hippocampus. However, the improvements induced by berberine were totally blocked by the pretreatment of miR-34a agomir, which caused the elevation of miR-34a levels in the hippocampus. Conclusion: This finding demonstrated that miR-34a downregulation was involved in the antidepressant-like effects of berberine in mice exposed to chronic stress.

13 Cytotoxicity of oleanane type triterpene from leaf extract of Pterospermum acerifolium (in vitro) and theoretical investigation of inhibitory signaling pathway

Mohd Rehan , Shafiullah Sultanat

2021, 13(1). DOI: 10.1016/j.chmed.2020.09.004

[Abstract](452) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
Objective: To evaluate the cytotoxic activity of taraxerol isolated from the leaves of Pterospermum acerifolium and its EtOH extract against human breast, colon, and lung cancer cell lines and docking studies. Methods: The structures of the isolated compounds were elucidated by several spectroscopic methods such as 1H-NMR, 13C-NMR, DEPT-135, COSY, HSQC, and HMBC. The extract and isolated compound were analyzed for cytotoxic activity on MDA-MB-231, BT-549, A-549, and SW-480 cancer cell lines by MTT assay. Molecular docking was performed on software such as Chem3D pro 12.0.2.1076, Discovery Studio Visualizer, Auto Dock Tools-1.5.6 and Auto dock vina. Results: The extract and isolated compound taraxerol both displayed excellent inhibitory activity (IC50: 80 μg/mL for extract and 160 g/mL for compound) on breast cancer cell (MDA-MB-231). The docking studies show a strong affinity with PI3K (-9.8 Kcal/mol) and mTOR (-10.0 Kcal/mol). Conclusion: The results confirm that the extract and compound exhibited strong cytotoxicity on the MDA-MB-231 cancer cell. So, the extract and the compound may be useful in human chemotherapies.

14 Induction of long-term potentiation at Schaffer collateral-CA1 synapses in mice hippocampus after IMPX977 administration

Ni Song b , Chen Duan a , Ye Li c , Tian-xiu Qian a , Qi Wang b , Wei Zhao b , Xiao-ying Wang a

2021, 13(1). DOI: 10.1016/j.chmed.2020.05.012

[Abstract](392) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
Objective To investigate the effects of IMPX977 on long term potentiation (LTP) at Schaffer collateral-CA1 synapses in vitro and on methyl CpG binding protein 2 (Mecp2) expression in mice cortex and hippocampus. Methods Thirty-two C57BL/6 mice were randomly divided into four groups: control, olive oil (vehicle), IMPX977 low (5 mg/kg) and high (15 mg/kg) groups. Mice were administrated every other day orally for two weeks. Extracellular recording technique in vitro was used to record the effects of IMPX977 on Schaffer collateral-CA1 LTP pathway in acute mice hippocampal slices. The Mecp2 protein expression level was detected by Western blotting. Results Compared to the control group, vehicle did not alter the synaptic transmission in Schaffer collateral-CA1 synapses, however, IMPX977 at concentrations of 5 mg/kg and 15 mg/kg significantly enhanced fEPSP (field excitatory postsynaptic potential) slope in Schaffer collateral-CA1 pathway to (179.6 ± 17.8)% and (191.4 ± 21.4)%, individually 60 min after HFS, IMPX977 improved LTP induction significantly at Schaffer collateral-CA1 pathway at least. Also, IMPX977 significantly elevated MeCP2 protein level in cortex and hippocampus. Conclusion The effects of IMPX977 on synaptic transmission and Mecp2 protein expression provided convincing evidence that IMPX977 could be promising new drug candidates for Rett syndrome treatment.

15 Effect of green tea consumption in treatment of mild to moderate depression in Iranian patients living with HIV: A double-blind randomized clinical trial

Dehghan Manshadi , Seyed Ali a , Mousavi , Seyed Alireza b , Salehi , Mohammad Reza a , Zebardast , Jayran c , SeyedAlinaghi , SeyedAhmad d , Rezazade , Shams Ali e , Mirhoseinian , Seyed Saeid f , Asadollahi-Amin , Ali d

2021, 13(1). DOI: 10.1016/j.chmed.2020.08.002

[Abstract](492) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
Objective: Depression affects people living with HIV (PLWH) compliance leading to poor control infection. Previous observational studies showed an anti-depression effect of green tea extract (GTE). The therapeutic effect of GTE on depression were investigated in PLWH receiving antiretroviral therapy (ART). Methods: Fifty PLWH on ART with diagnose of mild to moderate of depression, participated in a double-blind, placebo-controlled trial and underwent 12 weeks of treatment with either 400 mg GTE capsules or placebo twice daily. The Hamilton depression scale of patients was measured before, 6 weeks and 12 weeks after treatment in two groups. The primary outcome measure was performed to evaluate the efficacy of GTE in improving depressive symptoms. Results: The mean of Hamilton score showed a significant difference between the two groups after 12 weeks (P = 0.035). Repeated measures ANOVA test showed a significant effect for time × treatment interaction on the Hamilton mean score between the two groups (P = 0.000). Conclusion: It seems the use of GTE capsules in PLWH on ART is safe and could lead to greater and more rapid improvement in depressive symptoms than placebo. Thus it can be considered as an alternative therapy for mild to moderate depression. Further studies with higher sample size and longer follow-up and comparisons with other antidepressive drugs are warranted.

16 Building the highland of China-ASEAN talent exchange and cooperation

Xiao-tao Hou , Chang-xiao Liu

2021, 13(1).

[Abstract](174) [HTML](0) [PDF 0.00 Byte](0)

Abstract:
The fourth China-ASEAN Training Course on traditional Medicine and Crop waste medical Research technology was successfully held on December 21 at Guangxi University of Traditional Chinese Medicine (GXUTCM). Nanning, Guangxi. Aim at further promoting the exchange and cooperation of traditional medicine between China and ASEAN countries, teaching the forefront of academic ideas and experimental technology, and training more traditional medicine research professionals for ASEAN countries. The training course was hosted by GXUTCM, and organized by China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research, Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues and Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica. The training courses were conducted "online + offline" live broadcast in multiple locations, chaired by Prof. Deng. At the opening ceremony, Leng Jing, the vice president of GXUTCM said, Since 2017, the school has successfully hosted 3 consecutive "China-ASEAN Workshop for Medicinal Study on Traditional Medicine and Agricultural Residues", and achieved good results. This year, the COVID-19 is spreading around the world. The university has given full play to the advantages of traditional medicine and actively responded to it. It has jointly obtained 7 Guangxi emergency special funds in collaboration with experts from Singapore and Thailand. She hoped that through this training, more professionals in traditional medicine research will be cultivated for ASEAN countries, and the exchanges and cooperation of traditional medicine between China and ASEAN countries will be further promoted. Academician Liu Chang-xiao, director of the China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research, said that since the establishment of the China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research, it has carried out a large number of academic exchanges, resource investigations and talent exchanges, and published Chinese and English Version "China-ASEAN Traditional Medicines", and organized experts to hold many international conferences and training courses. It is hoped that through this training course, ASEAN trainees can gain more knowledge, technology and skills, and make greater contributions to the development of traditional medicines and crop waste medicinal resources in ASEAN countries. He said ‘I would like to thank the Guangxi Autonomous Region Government, the Guangxi Science and Technology Department and the Administration of Traditional Chinese Medicine for their strong support, and especially thank Guangxi University of Chinese Medicine for its contribution to organizing this workshop. The training focused on new methods and new technologies for the medicinal value research of traditional medicines and agricultural residues, carry out training on the advanced technologies including quality standards and quality control of TCMs, the mechanism of TCM prevention and treatment of infectious diseases, precision targeted metabolomics and transformational innovation of Chinese medicine, separation of new compounds, structure identification and biological activity evaluation. Specially invited professor Zhao Zhong-zhen from Hong Kong Baptist University, professor Bai Gang from Nankai University, researcher Lv Hai-tao from Shanghai Jiaotong University, professor Zhu Guo-yuan from Macau University of Science and Technology, professor Hou Xiao-tao from GXUTCM, and Dr. Tang Pei-ling, senior lecturer at the Tunku University College, to give lectures. More than 50 people from 10 ASEAN countries including Malaysia, Indonesia, Thailand, the Philippines, Singapore, Brunei, Vietnam, Laos, Myanmar, and Cambodia Participated in online learning, the number of students was twice as before. At the same time, it is open to teachers and students of GXUCTM and colleagues in the field. A total of more than 200 people participated in this training online, which has received positive responses!

Volume 13,Issue 1,2021 Table of Contents

Current Issue

Volume

Issue

Most Read

Most Cited

Most Downloaded

WeChat

Mobile website