Volume 3,Issue 4,2011 Table of Contents

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  • 1  A New Cyano-compound from Rhodiola kirilowii
    YANG Lian-mei HU Rong FU Hong-zheng
    2011, 3(4):241-243. DOI: 10.3969/j.issn.1674-6384.2011.04.001
    [Abstract](1641) [HTML](0) [PDF 202.61 K](2287)
    Abstract:
    Objective To study the chemical constituents of Rhodiola kirilowii. Methods The compounds were separated and purified by various chromatographic techniques and their structures were elucidated on the basis of physicochemical properties and spectroscopic methods. Results Five compounds were purified and their structures were identified as 4-(β-D-glucopyranosyloxy)-3-hydroxy-2-(hydroxymethyl)-butanenitrile (1), epicatechin (2), arbutin (3), rutin (4), and β-D-glucose (5). Conclusion Compound 1 is a new cyano-compound and other compounds are isolated from the plant for the first time.
    2  A New Stigmasterol Ester from Aeschynomene indica
    CHEN Jia-yuan TAN Xiao LU Wen-jie YA Qi-kang
    2011, 3(4):244-246. DOI: 10.3969/j.issn.1674-6384.2011.04.002
    [Abstract](1911) [HTML](0) [PDF 136.79 K](3789)
    Abstract:
    Objective To study the chemical constituents of Aeschynomene indica. Methods The constituents were isolated and purified by means of silica gel column chromatography and recrytallization, and the structures were elucidated by physicochemical properties and spectral analyses. Results Twelve compounds were obtained and elucidated as stigmasterol tritriacontanate (1), monotetracontane (2), taraxerol (3), stigmasterol (4), stearic acid (5), heptatria- contanoic acid (6), arachidic acid (7), ursolic acid acetate (8), quercetin (9), myricetin (10), myricetin-3-O- rhamnoside (11), and rutoside (12). Conclusion All the compounds are isolated from this plant for the first time and compound 1 is a new one.
    3  Ensuring Compliance of Raw Herbal Materials Stemmed from China with European Good Agricultural and Collection Practice
    ANDRE Philippe SU Hao-bo GAO Wen-yuan
    2011, 3(4):247-252. DOI: 10.3969/j.issn.1674-6384.2011.04.003
    [Abstract](1857) [HTML](0) [PDF 214.34 K](2525)
    Abstract:
    A “simplified” European procedure now allows the registration of traditional herbal medicines as medicinal products even without the support of clinical data. This procedure entails the requirement that those products comply with European Good Manufacturing Practice for medicinal products, which in turn implies that the raw herbal materials comply with the European Guidelines for Good Agricultural and Collection Practice. On the basis of a comparison between European Good Agricultural and Collection Practice and China Good Agricultural Practice, as well as direct observation made at sites in China, we issue some recommendations to facilitate good communication between the Chinese producer and European pharmaceutical customer, with a view to ensure full compliance with European expectations.
    4  New Progress in Modern Research on Chinese Herbal Medicines Published in Chinese Traditional and Herbal Drugs in 2010: Annual Highlights and Comments
    HE Chun-nian LIU Yan-ze XIAO Pei-gen
    2011, 3(4):253-261. DOI: 10.3969/j.issn.1674-6384.2011.04.004
    [Abstract](1668) [HTML](0) [PDF 524.88 K](2906)
    Abstract:
    As a series of and continuous publication, the papers published on Chinese Traditional and Herbal Drugs in 2010 were selectively and briefly highlighted to reflect the new progress on modern research of Chinese herbal medicines. Within 617 articles, chemical constituents (127), pharmaceutics and technology (149), pharmacological studies and clinical observation, and medicinal materials are still major categories. Some comments have also been personally provided.
    5  Pharmacological Effects of Mangiferin
    WEI Zhi-quan DENG Jia-gang YAN Li
    2011, 3(4):262-267. DOI: 10.3969/j.issn.1674-6384.2011.04.005
    [Abstract](1420) [HTML](0) [PDF 119.39 K](4759)
    Abstract:
    Mango leaves have been widely used in the clinical practice for thousands of years in traditional Chinese medicine. Mangiferin, an effective constituent in the mango leaves, has multiple pharmacological actions involved in some basic pathological processes, such as inflammation, oxidative injury, tumor growth, micro-organism infections, metabolic regulations, and immunological regulations. The pharmacological effects of mangiferin from some published data are reviewed in this article.
    6  New Collection of Crude Drugs in Chinese Pharmacopoeia 2010 II. Sankezhen (Berberis spp.)
    DAN Yang LIU Yan-ze PENG Yong QIAN Zhong-zhi XIAO Pei-gen
    2011, 3(4):268-284. DOI: 10.3969/j.issn.1674-6384.2011.04.006
    [Abstract](1832) [HTML](0) [PDF 312.11 K](4785)
    Abstract:
    Sankezhen (Berberidis Radix) is a traditional Chinese materia medica, cold in nature and bitter in taste, for treating syndromes of liver, stomach, and large intestinal meridians, in which berberine and berbamine are the major pharmacological components. Sankezhen has been readmitted in Chinese Pharmacopoeia 2010 following the 1977 version as the roots of Berberis spp. e.g. B. soulieana, B. wilsonae, B. poiretii, B. vernae, etc. Recent studies showed that Berberis spp. were potential phytomedicines with multiple spectrums therapeutic effects and various pharmaceutical parts. Here we reviewed Sankezhen in traditional use and phytochemistry, and its major active components berberine and berbamine with potential bioactivities recently discovered, such as antitumor, antidiabetic, antihyperlipidemic, anti-arrhythmic, and neuro-protective activities. It is necessary to mature the quality assessment of Sankezhen as a new admission of Chinese Pharmacopoeia 2010. Other parts of Berberis spp. should be investigated to better develop this herb in medicinal usage.
    7  Visualization of Multivariate Metabolomic Data
    ZHOU Jun AA Ji-ye WANG Guang-ji ZHANG Feng-yi GU Rong-rong WANG Xin-wen ZHAO Chun-yan LI Meng-jie SHI Jian CAO Bei ZHENG Tian LIU Lin-sheng GUO Sheng DUAN Jin-ao
    2011, 3(4):285-289. DOI: 10.3969/j.issn.1674-6384.2011.04.007
    [Abstract](1295) [HTML](0) [PDF 310.53 K](3732)
    Abstract:
    Objective Although principal components analysis profiles greatly facilitate the visualization and interpretation of the multivariate data, the quantitative concepts in both scores plot and loading plot are rather obscure. This article introduced three profiles that assisted the better understanding of metabolomic data. Methods The discriminatory profile, heat map, and statistic profile were developed to visualize the multivariate data obtained from high-throughput GC-TOF-MS analysis. Results The discriminatory profile and heat map obviously showed the discriminatory metabolites between the two groups, while the statistic profile showed the potential markers of statistic significance. Conclusion The three types of profiles greatly facilitate our understanding of the metabolomic data and the identification of the potential markers.
    8  Inhibition of Corydalis decumbens Alkaloids on Hydrogen Peroxide- induced Apoptosis of PC12 Cells through Down-regulating Caspase-3 Expression
    YAN Ren-jie YANG Yi-fang LUO Yong-ming WU Chun-zhen
    2011, 3(4):290-295. DOI: 10.3969/j.issn.1674-6384.2011.04.008
    [Abstract](1350) [HTML](0) [PDF 267.76 K](2628)
    Abstract:
    Objective To extract alkaloids from Corydalis decumbens (AsCD) by supercritical CO2 fluid extraction (SFE) and to evaluate protective effects of AsCD against hydrogen peroxide (H2O2)-induced apoptosis in rat PC12 cells. Methods AsCD were extracted by SFE and oxidative damage PC12 cells model was induced by H2O2. The survival rate of the cells was determined by MTT assay; Lactate dehydrogenase release was determined by ultraviolet spectrophotometry; Flow cytometry was used to detect apoptosis; Caspase-3 mRNA and protein were determined by real-time PCR and Western blotting assay, respectively. Results AsCD remarkably reduced the cytotoxicity, prevented membrane damage, and inhibited cell apoptosis. AsCD inhibited Caspase-3 mRNA and protein expression induced by H2O2 in PC12 cells. Conclusion AsCD possess protective effects against H2O2-induced apoptosis in PC12 cells, and the mechanism of AsCD responsible to the inhibition of apoptosis is possibly attributed to the down-regulating Caspase-3 expression. AsCD might be useful in the treatment of oxidative stress-related neurodegenerative diseases.
    9  “Dose-effect-response” Relationships of Paeoniae Radix Rubra on α-Naphthylisothiocyanate-induced Acute Cholestatic Hepatitis in Rats
    WEI Si-si ZHAO Yan-ling JIANG Feng-juan JIA Lei ZHU Yun WANG Jia-bo SUN Zhi-yong LI Rui-sheng XIAO Xiao-he
    2011, 3(4):296-303. DOI: 10.3969/j.issn.1674-6384.2011.04.009
    [Abstract](1202) [HTML](0) [PDF 1.41 M](3372)
    Abstract:
    Objective To investigate the hepatoprotective effects of Paeoniae Radix Rubra (PRR) at different doses against α-naphthylisothiocyanate (α-NIT)-induced acute cholestatic hepatitis in rats. Methods Rats were ig admini- strated with vehicle or PRR [(1, 9, 18, 36, 54, 72, and 81 g/(kg?d)] 3 d before and 2 d after α-NIT (60 mg/kg) ig administration. The general status of rats, histopathology of liver, serum alanine aminotransaminase, aspartate aminotransaminase, total bilirubin, direct bilirubin, and alkaline phosphatase levels, were observed at respective time points (24 and 48 h) after α-NIT administration. Using cluster analysis and correspondence analysis, the “dose-effect-response” relationships of PRR were evaluated. Results The results showed that compared with model group, the serum biochemistry index significantly decreased with the increasing of PRR dosage (P < 0.01), and the change and necrosis of hepatic cellula, and inflammatory cell infiltration were gradually alleviated. However, the improvement was not obviously found in the low-dose group [1 g/(kg?d)]. The cluster analysis and correspondence analysis results showed that different doses of PRR could significantly ameliorate α-NIT-induced acute cholestatic hepatitis of rats in a dose-dependent manner. Conclusion The experiments show that administration doses of PRR in clinical use should be added properly in order to gain the expectant therapeutic effect, especially in the treatment of heavy acute cholestasis hepatitis.
    10  Simultaneous Determination of Silybin A and Silybin B in Rat Plasma and Pharmacokinetic Study
    CHU Yang LI Wei LI Zhi-wen LI Xin-xin MA Xiao-hui ZHOU Shui-ping ZHU Yong-hong
    2011, 3(4):304-309. DOI: 10.3969/j.issn.1674-6384.2011.04.010
    [Abstract](1843) [HTML](0) [PDF 253.99 K](2854)
    Abstract:
    Objective To investigate the bioavailability and pharmacokinetics of silybin A and silybin B in rats, respectively. Methods Following iv and ig administration of silybin to 20 Wistar rats, the plasma samples were collected at different time points up to 12 h. Sample pretreatment was involved in one-step protein precipitation with acetonitrile. Silybin A and silybin B were simultaneously determined by LC-MS/MS. Results After ig dosing silybin 28, 56, and 112 mg/kg to rats, the t1/2β values were 5.48, 5.08, and 5.73 h for silybin A, and 4.56, 4.12, and 5.53 h for silybin B; The Cmax were 674.3, 1349.4, and 2042.5 ng/mL for silybin A, and 671.0, 1365.4, and 2066.2 ng/mL for silybin B; The Tmax were 0.20, 0.23, and 0.20 h for silybin A, and 0.20, 0.23, and 0.20 h for silybin B; The AUC were 454.4, 845.9, and 1219.5 h?ng/mL for silybin A, and 432.0, 817.1, and 1153.6 h?ng/mL for silybin B. The absolute bioavailabilities of silybin A and silybin B were 2.86% and 1.93%, respectively. Conclusion Silybin A and silybin B have very low bioavailability after ig administration, and there is no significant difference in the pharmacokinetic parameters between silybin A and silybin B, which indicates that the two diastereoisomers have similar pharmacokinetic behavior in rats.
    11  Meta Analysis of Lentinan Injection plus Cisplatin in Treatment of Malignant Pleural Effusion
    WANG Quan HE Xi-ran WANG Man-cai TIAN Jin-hui
    2011, 3(4):310-318. DOI: 10.3969/j.issn.1674-6384.2011.04.011
    [Abstract](1337) [HTML](0) [PDF 203.55 K](2450)
    Abstract:
    Objective To evaluate the efficacy and safety of lentinan injection plus cisplatin (LIC) in the treatment of malignant pleural effusion (MPE). Methods We searched the database of Cochrane Library, PubMed, EMBASE, ISI Web of Knowledge, Chinese Biomedical Literature Database, Chinese Scientific Journals Full-text Database, Chinese Journal Full-text, and Google Scholar, etc., up to February 28th, 2011 to identify randomized controlled trials (RCTs) about lentinan injection (LI) for MPE, evaluate the quality of the included studies, and analyze the data by Cochrane Collaboration’s RevMan5.0 software. Results Twenty-nine RCTs involving 1831 patients were included. Meta analysis results suggested that there were some differences when comparing LIC with control groups suffering from MPE, for LIC could improve the near-term curative effect and the quality of life to some extent. Besides, compared with chemotherapy alone, LI plus chemotherapy had an advantage in relieving adverse reactions, such as gastrointestinal reactions, myelosuppression, chest pain, and general malaise. Conclusion The current evidence indicates that LI may have adjuvant therapeutic effects for MPE.

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