Objective: To study the compounds isolated from Penicillium HDS-Z-1E, an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase (CAT). Methods: The chemical constituents were isolated from Penicillium HDS-Z-1E, by using silica gel, Sephadex LH-20 and HPLC. The structural elucidations of five metabolites were elucidated on the basis of spectroscopic including 1H NMR, 13C NMR, HMBC and HSQC. Their activation sites of catalase have been investigated by molecular docking. Results: Five metabolites, compounds (1–5) were isolated from Penicillium HDS-Z-1E and identified as 4-hydroxy-4-methyltetrahydro-2H-pyran-2-one (1), 4-hydroxymethyl-5, 6-dihydro-pyran-2-one (2), 5, 6-dihydro-2-oxo-2H-pyran-4-carboxylic (3), N-acetyl hydrazinobenzoic acid (4), and methyl 2-(2, 5-dihydroxyphenyl) acetate (5). Conclusion: Compound 3 is a new compound. Compounds 3 and 4 may have potential activators of catalase, providing a theoretical basis for the development of CAT activators.
关键词:
过氧化氢酶激动剂;分子模拟;青霉属;矮紫杉;、4-羧基-5，6-二氢吡喃酮
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Project Supported:
This work was supported by Excellent Youth Team for Scientific Research, Innovation and Entre-preneurship of Dalian University (No. XQN202004).
Chuan Tang, Rui Gao, Xiaoyuan Tang, Yu Zhang, Weixing Feng, Baomin Feng, Xuan Lu *. Metabolites isolated from Penicillium HDS-Z-1E, an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase[J]. Chinese Herbal Medicines (CHM),2024,16(2):227-230
