Effect of green tea consumption in treatment of mild to moderate depression in Iranian patients living with HIV: A double-blind randomized clinical trial
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摘要:
Abstract:
Objective: Depression affects people living with HIV (PLWH) compliance leading to poor control infection. Previous observational studies showed an anti-depression effect of green tea extract (GTE). The therapeutic effect of GTE on depression were investigated in PLWH receiving antiretroviral therapy (ART). Methods: Fifty PLWH on ART with diagnose of mild to moderate of depression, participated in a double-blind, placebo-controlled trial and underwent 12 weeks of treatment with either 400 mg GTE capsules or placebo twice daily. The Hamilton depression scale of patients was measured before, 6 weeks and 12 weeks after treatment in two groups. The primary outcome measure was performed to evaluate the efficacy of GTE in improving depressive symptoms. Results: The mean of Hamilton score showed a significant difference between the two groups after 12 weeks (P = 0.035). Repeated measures ANOVA test showed a significant effect for time × treatment interaction on the Hamilton mean score between the two groups (P = 0.000). Conclusion: It seems the use of GTE capsules in PLWH on ART is safe and could lead to greater and more rapid improvement in depressive symptoms than placebo. Thus it can be considered as an alternative therapy for mild to moderate depression. Further studies with higher sample size and longer follow-up and comparisons with other antidepressive drugs are warranted.
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This project had the financial support of the Vice-Chancellor of Research in Tehran University of Medical Sciences (TUMS). The trial was registered at the Iranian registry of clinical trials (http://www.irct.ir; registration number: IRCT2017071128308N2) and was approved by Imam Khomeini Hospital Ethics Committee (reference number: IR.TUMS.MEDICINE.REC.1396.3572). We are also grateful to the staff of Imam Khomeini Hospital VCT center and Iranian Institute of Medicinal Plants providing the green tea capsule. This project dedicates to distinguished Professor Alireza Yalda.
Dehghan Manshadi, Seyed Ali a, Mousavi, Seyed Alireza b, Salehi, Mohammad Reza a, Zebardast, Jayran c, SeyedAlinaghi, SeyedAhmad d, Rezazade, Shams Ali e, Mirhoseinian, Seyed Saeid f, Asadollahi-Amin, Ali d. Effect of green tea consumption in treatment of mild to moderate depression in Iranian patients living with HIV: A double-blind randomized clinical trial[J]. Chinese Herbal Medicines (CHM),2021,13(1):
