Challenges and strategies in progress of drug delivery system for traditional Chinese medicine Salviae Miltiorrhizae Radix et Rhizoma (Danshen)
Traditional Chinese medicines (TCMs), with a history of thousands of years, are widely used clinically with effective treatment. However, the drug delivery systems (DDSs) for TCMs remains major challenges due to the characteristics of multi-components including alkaloids, flavones, anthraquinones, glycosides, proteins, volatile oils and other types. Therefore, the novel preparations and technology of modern pharmaceutics is introduced to improve TCM therapeutic effects due to instability and low bioavailability of active ingredients. Salviae Miltiorrhizae Radix et Rhizoma, the radix and rhizomes of Salvia miltiorrhiza Bunge (Danshen in Chinese), is a well known Chinese herbal medicine for protecting the cardiovascular system, with active ingredients mainly including lipophilic tanshinones and hydrophilic salvianolic acids. In this review, this drug is taken as an example to present challenges and strategies in progress of DDSs for TCMs. This review would also summary the characteristics of active ingredients in it including physicochemical properties and pharmacological effects. The purpose of this review is to provide inspirations and ideas for the DDSs designed from TCMs by summarizing the advances on DDSs for both single- and multi-component from Danshen.
The authors acknowledge financial support from National Natural Science Foundation of China (No. 81903557，82074024), Natural Science Foundation of Jiangsu Province (No. BK20190802), Natural Science Foundation Youth Project of Nanjing University of Chinese Medicine (No. NZY81903557) and Natural Science Foundation of the Jiangsu Higher Education Institutions of China (No. 19KJB350003).
Ruo-ning Wanga, b, Hua-cong Zhao a, b, Jian-yu Huang a, b, Hong-lan Wang a,, Jun-song Li a, b, Yin Lua, c, Liu-qing Di a, b. Challenges and strategies in progress of drug delivery system for traditional Chinese medicine Salviae Miltiorrhizae Radix et Rhizoma (Danshen)[J]. Chinese Herbal Medicines (CHM),2021,13(1):
Online Published: January 18,2021
Chinese Herbal Medicines (CHM) ® 2021 All Rights Reserved