Immunomodulatory effects and structure-activity relationship of botanical pentacyclic triterpenes: A review
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摘要:
Abstract:
Botanical pentacyclic triterpenes possessed a broad range of pharmacological activities such as anti-oxidant, anti-tumor, anti-microbial and anti-in?ammatory. It is believed that the mechanisms involved in these bioactivities are due to the modulation of immune system. Recently, the pharmacological validation on immunomodulatory of pentacyclic triterpenes derived from higher plants is very limited and several existence review papers related for this group of compound have not been focused for this activity. In this review, we have highlighted several studies on immunomodulatory potential of botanical pentacyclic triterpenes isolated from wide array of different species of medicinal plants and herbs based on various preclinical in vitro and animal models. This review also attempts to discuss on bioactivities of this compound related with their structure-activity relationship. Hence, the evaluation of this botanical pentacyclic triterpenes offers a great opportunity to discover adjuvants and novel therapeutic agents that presented beneficial immunomodulatory properties.
Nurul Hikmah Haruna, b, Abdi Wira Septamac, Wan Amir Nizam Wan Ahmada, Rapeah Suppiana. Immunomodulatory effects and structure-activity relationship of botanical pentacyclic triterpenes: A review[J]. Chinese Herbal Medicines (CHM),2020,12(2):
