In vivo investigation of antimicrobial effects of cinnamaldehyde using immunosuppressed ICR mice with invasive pulmonary aspergillosis
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摘要:
目的：评价雷公藤多苷联合缬沙坦治疗糖尿病肾病（DN）的疗效和安全性。 方法：本文对12个电子数据库进行综合研究。被纳入的研究分别由两位作者独立使用Review Manager（版本5.2）和Stata（版本12.0）进行提取和分析。 结果：共纳入12项随机对照试验，涉及829例患者。结果表明，联合用药能显著提高DN患者的总有效率（RR = 1.35, 95%CI [1.22, 1.50], P < 0.001）及血清白蛋白水平（平均差（MD） = 3.87, 95%CI [3.12, 4.62], P < 0.001），并显著降低24小时尿蛋白水平 (MD = 0.97, 95%CI [1.19, 0.76], P < 0.001）、尿白蛋白排泄率 (MD = 145.53, 95%CI [227.95, 63.11], P < 0.001）及尿β2微球蛋白水平 (MD = 11.86, 95%CI [13.02, 10.69], P < 0.001)。血清肌酐 (MD = 0.26, 95%CI [7.52, 7.00], P > 0.05)，血尿素氮 (MD = 0.25, 95%CI [0.23, 0.74], P > 0.05) 和内源性肌酐清除率 (MD = 0.43, 95%CI [3.48, 2.62], P > 0.05) 无显著性差异。雷公藤多苷联合缬沙坦组不良反应发生率明显高于缬沙坦单药治疗组 (MD=3.41, 95%CI [1.34, 8.66], P < 0.05)。所纳入的所有监测指标均不存在发表偏倚。 结论：雷公藤多苷联合缬沙坦治疗DN疗效确切。然而，联合治疗的安全性有待进一步证实。
Abstract:
Objective: Growing problem of antibiotic resistance in Helicobacter pylori, as a common cause of chronic gastritis and even stomach cancer, demands searching for novel candidates of herbal sources. This study is aimed at assessing the antimicrobial activity of aqueous extract obtained from Quercus brantii var. persica seed coat (Testa) on H. pylori isolated from gastric biopsy specimens. Methods: Such specimens were collected from 100 patients presenting with endoscopic gastroduodenal findings. Testa extracts were prepared from Persian Oak forests in the province of Kohgiluyeh and Boyer-Ahmad, IRAN. H. pylori isolates were obtained by a series of standard bacteriology tests and cell culture, then were confirmed by PCR. The activity of testa extracts towards 25 H. pylori isolates was assessed by well diffusion method, microdilution assay, and a disk diffusion assay in vitro. Results were analyzed statistically by one-way ANOVA analysis. Results: Aqueous extract of testa demonstrated an antimicrobial activity with zone diameters of inhibition ranged from 0 mm to 40 mm. Its inhibitory activity increased simultaneously with increasing extract concentration. The lowest MIC and MBC were both recorded as 2 μg/mL. Anti-H. pylori activity of testa extract was approximately close to tetracycline and metronidazole and less than amoxicillin. A potent extract of testa possessed significant inhibitory activity (P < 0.05). Conclusion: Testa extract is suggested as a natural therapeutic source against the gastric H. pylori infection. However, evaluating the in vivo activity of this extract is necessary too.
关键词:
糖尿病肾病;荟萃分析;雷公藤多苷;缬沙坦
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This work has received research grant support (MICRO_96_A2) from Yasuj University of Medical Sciences. This work was supported by Yasuj University of Medical Sciences, Yasuj, Iran.
Asghar Sharifi, Mohsen Azizi, Parastoo Moradi-Choghakabodi, Shapour Aghaei, Arsalan Azizia. In vivo investigation of antimicrobial effects of cinnamaldehyde using immunosuppressed ICR mice with invasive pulmonary aspergillosis[J]. Chinese Herbal Medicines (CHM),2019,11(4):429-433
