Chemical Constituents from Mycelia and Spores of Fungus Cordyceps cicadae
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摘要:
Abstract:
Objective To isolate and identify the chemical constituents from mycelia and spores of the fungus Cordyceps cicadae, respectively. Methods The chemical constituents were isolated and purified by repeated silica gel, Sephadex LH-20, and reversed phase HPLC. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR. Results Nine known sterols such as ergosterol (1), ergosterol peroxide (2), 9,11-dehydroergosterol peroxide (3), 3β,5α,9α- trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (4), 3β,5α,9α,14α-tetrahydroxy-(22E, 24R)-ergosta-7,22-dien-6-one (5), 5α,6α-epoxy-(22E,24R)-ergosta-8(14),22-diene- 3β,7α-diol (6), 3β,5α,6β-(22E,24R)-ergosta-7,22-dien-3,5,6-triol (7), 3β,5α,6α-6- methoxyergosta-(22E,24R)-7,22-diene-3,5-diol (8), 4-hydroxy-17R-methylincisterol (9), together with a resorcinol derivative, 5-n-nonadecylresorcinol (10), a cyclo- desipeptide, beauvericin (11), and a nucleoside, N6-(2-hydroxyethyl)adenosine (12) were successively isolated from the cultivated C. cicadae mycelia and spores. Conclusion Compounds 3?10 are reported for the first time from the title sample, beauvericin exhibits significant cytotoxicity against human leukemia cell line and human lung cancer cell line.
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Project Supported:
National Natural Science Foundation of China (No. 81520108028, 81273430, 41306130, 81302692, 41676073, 81603022); SCTSM Project (No. 14431901100, 15431901000); Institutes for Drug Discovery and Development, Chinese Academy of Sciences (No. CASIMM0120152039); SKLDR/SIMM Projects (SIMM 1501ZZ-03); “Youth Innovation Promotion Association” from Chinese Academy of Sciences (No. 2016258); “Young Talent Supporting Project” from China Association for Science and Technology (No. 2016QNRC001); Shanghai “Pujiang Program” (No. 16PJ1410600)
Jia-hui Wang, Zhong-liang Zhang, Yu-qin Wang, Min Yang, Chun-hua Wang, Xu-wen Li, Yue-wei Guo. Chemical Constituents from Mycelia and Spores of Fungus Cordyceps cicadae[J]. Chinese Herbal Medicines (CHM),2017,9(2):188-192
