Components in Antineoplastic Actinomycete Strain (N2010-37) of Bottom Mud in Mangrove
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Abstract:
Objective To study the antitumor components from an actinomycete strain (N2010-37) of bottom mud in Zhanjiang Mangrove, South China Sea. Methods The components were isolated and purified by chromatographic techniques and recrystallization, and the structures were identified by spectral methods together with physicochemical analyses. The antitumor effects of these components were tested in vitro by MTT method. Results Three compounds were identified including two anthrones and one novel lactone. They are (3S,4R,7R,8R,9S)-3,8-dihydroxy-4,7,9-trimethyl- 2,6-cyclononanediolacetone (1), 2-hydroxy-1-methoxy-3-methylanthraquinone (2), and 1,6,8-thihydroxy-3-methyl- anthraquinone (3). Conclusion Compound 1 is a new compound, and compounds 1 and 3 show the favorable cytotoxic activities against human chronic granulocytic leukemia cell line K562 strain by MTT method in vitro.
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Foundation for Distinguished Young Talents in Higher Education of Guangdong, China (LYM09100)
ZHOU Zhong-liu, JIN Bei, YIN Wen-qing, FU Chun-yan, FENG Hua-fen. Components in Antineoplastic Actinomycete Strain (N2010-37) of Bottom Mud in Mangrove[J]. Chinese Herbal Medicines (CHM),2011,3(3):165-167
