10月24日，中草药杂志社组织召开了2023年4刊编委会，在遵循公平、公正、公开原则的基础上，结合发表论文在数据库中引用和下载情况，经过专家评审严格筛选，评选出了2020-2023 年发表在杂志社4刊上的优秀论文10篇。

获得 2020-2023 年中草药杂志社优秀论文奖的10篇论文是：

Chinese Herbal Medicines（CHM ）4篇：

①  题目：Pay attention to situation of SARS-CoV-2 and TCM advantages in treatment of novel

作者：Changxiao Liu（刘昌孝，天津药物研究院）

摘要：Since the outbreak of the new coronavirus epidemic, novel coronavirus has infected nearly 100,000 people in more than 110 countries. How to face this new coronavirus epidemic outbreak is an important issue. Basic reproduction number (R0) is an important parameter in epidemiology; The basic reproduction number of an infection can be thought of as the expected number of cases directly generated by one case in a population where all individuals are susceptible to infection. Epidemiology dynamics is a mathematical model based on a susceptibility-infection-recovery epidemic model. Researchers analyzed the epidemiological benefits of different transmission rates for the establishment of effective strategy in prevention and control strategies for epidemic infectious diseases. In this review, the early use of TCM for light and ordinary patients, can rapidly improve symptoms, shorten hospitalization days and reduce severe cases transformed from light and normal. Many TCM formulas and products have wide application in treating infectious and non-infectious diseases. The TCM theoretical system of treating epidemic diseases with TCM and the treatment scheme of integrated Chinese and Western medicine have proved their effectiveness in clinical practice. TCM can cure COVID-19 pneumonia, and also shows that the role of TCM in blocking the progress of COVID-19 pneumonia.

作者简介：

刘昌孝 院士

中国工程院院士、研究员、博士研究生导师。现任天津药物研究院名誉院长、终身首席科学家和学术委员会主任，中国-东盟传统药物国际合作联合实验室主任，国务院发展研究中心健康中国促进网中医药院士专家中心主任、国家科技奖励评审专家、国家药监局中药监管科学研究中心专家委员会主任、中国药典委员会顾问、中国药学会常务理事、中国医学科学院学部委员、中国中医科学院学部委员和执行委员、国际药物代谢研究会中国办事处主任、国家药品监督管理局仿制药一致性评价专家委员会副主任、天津市药学会会长、天津市药品监管科学研究会理事长、天津市学会学研究会名誉理事长。

刘昌孝是我国药代动力学的学科开拓者和学科带头人之一，从事药理学、药代动力学、现代中药和中药质量研究50余年，致力于生物医药发展战略研究，承担和参与多项生物医药战略咨询研究项目。承担过包括国家“973”和“863”项目、国家科技部国际合作项目、国家重大专项课题、国家自然科学基金重点项目等国家重大研究项目50余项，发表论文600多篇，在国内外出版中英文学术专著38部。曾获得国务院特殊津贴(1992)，香港紫金花医学成就奖（2000），香港紫荆花医学创新金奖（2000），天津市劳动模范（2000），全国劳动模范（2005），全国优秀科技工作者（2012），国际药物代谢研究会“特别贡献奖（2013），天津市滨海科技突出成就奖（2016），中国药学会突出贡献奖（2017），世界中医药联合会中药分析与标准“终身成就奖”（2018），循证中医药研究“终身成就奖”（2020）、“卓越贡献奖”（2021），光华工程科技特别贡献奖（医药卫生学部全体院士，2020），中国药学会“最美科技工作者”称号（2021），国家科技进步奖二等奖（第一完成人，2020）。

②  题目：Phytochemicals and antioxidant activity of alcoholic/hydroalcoholic extract of Trifolium pratense

作者： Mohsen Akbaribazm, Mohammad Rasoul Khazaei, Mozafar Khazaei（伊朗克尔曼沙赫医科大学）

摘要：Objective: Trifolium pratense has many healing properties, including fewer complications of menopause, cancer cell suppression, reducing blood glucose and lipids, as well as cardiovascular beneficial effects. The purpose of this study was to identify the phytochemical and mineral composition of T. pratense. Methods: Plant aerial parts were harvested and dried, and then hydroalcoholic and alcoholic extracts were prepared. Gas chromatography–mass spectrometry (GC-MS) analytical method was used to identify volatile compounds then liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) was used to identify polyphenols and the mineral elements were identify by inductively coupled plasma atomic emission spectrometer/ICP-AES and scanning electron microscope-energy-dispersive X-ray spectroscopy (SEM-EDS) methods. Total phenolic content (TPC) was determined based on colorimetric method, and total flavonoid content (TFC) was established based on the folin-chiocalteau reagent. Furthermore, two assays (DPPH and FRAP) were used to measure the antioxidant capacity of T. pratense ethanolic extract. Results: A total of 37 polyphenol and 107 peaks were identified by LC-ESI-MS analysis, and the GC/MS method also detected 21 volatile compounds, the most important of which were methylcyclopentane, dimethylpentanal and hexadecanol. A total of 18 mineral elements, including K, Mg, Al, Si, Zn, Ni, Cu, Se, Co, Fe, Mn, and Ca in the plant, were identified ICP-AES and SEM-EDS analysis. Conclusion: T. pratense has many therapeutic compounds such as polyphenol (isoflavone and flavonoids), volatile compounds, and essential mineral elements, which can be formulated purely and used in the pharmaceutical and traditional medicine industries.

作者简介：

Prof. Mozafar Khazaei (Ph.D., M.Sc, B.Sc)

Head of Fertility and Infertility Research Center and Tissue Engineering Dep. in Medical School of Kermanshah University of Medical Sciences, with research interests in Histology, Tissue Engineering, Reproductive Biology, Cancer Biology, Diabetes and Herbal Medicine.

③  题目：In vitro and in silico anti-oxidant, cytotoxicity and biological activities of Ficus benghalensis

作者： Pukar Khanal, Basanagouda M. Patil（印度KLE高等教育研究院）

摘要：Objective: To report in vitro anti-oxidant activity and cytotoxicity of hydroalcoholic extract of Ficus benghalensis (bark) and Duranta repens(whole plant), and present the probable biological spectrum of major anti-oxidants from both plants. Methods: The coarse powder of both plants was first extracted with 70% ethanol (maceration) and followed by 99% ethanol (Soxhlet-extraction). Anti-oxidant activity of the extracts was evaluated by using DPPH, H2O2, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), NO scavenging assay, total antioxidant capacity, cupric reducing antioxidant capacity (CUPRAC), and metal chelating assay. Cytotoxicity of both extracts was evaluated by using MTT assay in both tumor and normal cell lines i.e. Chinese hamster ovary cells (CHO) and A549 cells. Biological activity of individual anti-oxidant compounds was identified by using prediction of activity spectra for substances and a docking study was performed by using autodock4.0. Results: Hydroalcoholic extract of F. benghalensis and D. repens showed the highest free radical scavenging capacity (ABTS) and chelating capacity respectively. Both extracts showed minimum cytotoxicity in normal cell lines compared to tumor cell lines. Computer imitation hits reflected the multiple biological activities agreeing with the folk use and some scientific reports. Further, we found the potent binding affinity of predicted anti-oxidant compounds with multiple protein molecules involved in oxidative stress. Conclusion: The present study reports the probable anti-oxidant mechanism for two folk agents and also presents probable pharmacological activities via computer simulations.

作者简介：

Dr. Pukar Khanal, Ph.D.

Dr. Pukar Khanal, Ph.D., was a university gold medalist in his undergraduate and postgraduate studies in the faculty of pharmaceutical science at the KLE Academy of Higher Education and Research, Belagavi, India. Dr. Khanal focuses on cross-linking brain glucotoxicity and/or insulin resistance with compromised neuronal signaling as a potential risk of developing cognitive impairment. He further attempts to identify novel disease-modifying interventions from the existing pool of small molecules against endocrine disturbances, neurological disorders, and cancer using both computational and experimental approaches, including the impact of psychotropic molecules in normal physiology. He seeks an approach to linking missing dots (manipulated biological spectra, cellular processes, immune regulation, and molecular function) in complex polygenic and rare diseases using a series of computational approaches followed by wet-lab experiments (in vitro studies including zebrafish and rodent models). Dr. Khanal extensively investigates the multitarget selectivity of small molecules from a deep compound pool to identify novel therapeutic applications through chemical fingerprinting. He believes this approach may neutralize the complex network of polygenic conditions, e.g., manipulated glucose metabolism (type 2 diabetes mellitus), altered neuronal signaling, and cognitive impairment (Alzheimer’s disease). Further, he sought to establish Danio rerio as a preliminary animal model for olanzapine-induced metabolic changes by assessing manipulated metabolic rate and compromised lipid metabolism.

Prof. Dr. B. M. Patil

Prof. Patil is currently affiliated with PRES’s Pravara Rural College of Pharmacy in Pravaranagar, Loni, Maharashtra, India, as the Professor and Director. Previously, he was affiliated as the Professor, Principal, and Dean of the Faculty of Pharmacy at KLE Academy of Higher Education and Research, Belagavi, India, and supervised doctorate and postgraduate students in their research. His research interests cover the pathophysiology of insulin resistance-induced endothelial dysfunction, cancer pharmacology, and neuropharmacology (Alzheimer’s and Parkinson’s disease). His expertise in experimental pharmacology includes ex vivo (isolated tissue experiments), in vitro (enzyme inhibition against postprandial hyperglycemia), and in vivo pharmacology. One of his key research interests is to identify a novel approach to addressing metabolic disturbances (mild hyperglycemia, hypertension, and weight gain) in olanzapine therapy. He uses computational pharmacology and its experimental validation to identify the multiple secondary metabolites in traditional medicines against various diseases. He uses computational pharmacology to screen the possible active ingredients from ethnobotanicals and observe the possible effects in vivo. He was awarded the “Prof. M.L. Khorana Memorial Award” for publishing the best research paper in the Indian Journal of Pharmaceutical Sciences. Further, he proposed that Danio rerio could be one of the preliminary animal models for olanzapine-induced weight gain.

④  题目：Pharmaceutical resource discovery from traditional medicinal plants

作者：Hao Da-cheng，Xiao Pei-gen（郝大程， 肖培根，大连交通大学）

摘要：The worldwide botanical and medicinal culture diversity are astonishing and constitute a Pierian spring for innovative drug R&D. Here, the latest awareness and the perspectives of pharmacophylogeny and pharmacophylogenomics, as well as their expanding utility in botanical drug R&D, are systematically summarized and highlighted. Chemotaxonomy is based on the fact that closely related plants contain the same or similar chemical profiles. Correspondingly, it is better to combine morphological characters, DNA markers and chemical markers in the inference of medicinal plant phylogeny. Medicinal plants within the same phylogenetic groups may have the same or similar therapeutic effects, thus forming the core of pharmacophylogeny. Here we systematically review and comment on the versatile applications of pharmacophylogeny in 1) looking for domestic resources of imported drugs, 2) expanding medicinal plant resources, 3) quality control, identification and expansion of herbal medicines, 4) predicting the chemical constituents or active ingredients of herbal medicine and assisting in the identification and determination of chemical constituents, 5) the search for new drugs sorting out, and 6) summarizing and improving herbal medicine experiences, etc. Such studies should be enhanced within the context of deeper investigations of molecular biology and genomics of traditional medicinal plants, phytometabolites and metabolomics, and ethnomedicine-based pharmacological activity, thus enabling the sustainable conservation and utilization of traditional medicinal resources.

作者简介：

郝大程 教授

大连交通大学教授，一直从事药用植物和植物药资源环境相关研究，已发表SCI论文近百篇，出版中文学术专著1部和英文学术专著3部，获得2020年中华中医药学会科学技术奖一等奖（3/11），授权发明专利两项，实用新型专利两项，获得国家级及省部级研究资助多项。担任4种SCI期刊编委和2种核心刊编委。

《中草药》4篇：

⑤  题目：丹参化学成分及其药理作用研究进展

作者：万新焕，王立柱（山东中医药大学）

摘要：丹参Salvia miltiorrhiza是一味临床常用的具有活血化瘀功效的中药。丹参有着广泛的药理作用，临床主要用于月经不调、心悸失眠及各种心血管疾病，尤其是心绞痛和心肌梗死等疾病的治疗。丹参化学成分是其发挥药理作用的重要物质基础，综述了丹参化学成分及其药理作用的国内外研究进展，分析丹参研究现状及研究方向，为其进一步开发利用提供一定的参考。

作者简介：

万新焕

山东中医药大学硕士生导师，山东中医药大学“重大疾病防治中药新药研制与产品开发青年科研创新团队”核心成员，主要从事药物新制剂与新剂型研究。兼任世界中医药学会联合会中医药抗病毒专业委员会理事，中国医药教育协会中医药教育促进工作委员会委员，山东中医药学会中药制剂专业委员会委员。主持山东省自然科学基金及山东中医药大学青年科学基金各1项，参与省部级课题2项，厅局级课题3项；以第一作者及通讯作者在Carbohydrate Polymers、Phytomedicine、J Chromatogr B Analyt Technol Biomed Life Sci发表SCI论文10余篇，累计影响因子达50以上；参编著作2部，获得软件著作权2项。

⑥  题目：茯苓化学成分和药理作用研究进展及质量标志物的预测分析

作者：邓桃妹，陈卫东（安徽中医药大学）

摘要：茯苓Poria cocos是我国传统的药食同源中药材，具有利水渗湿、健脾、宁心等功效，在药品、食品及保健品中均有广泛应用。随着对茯苓的深入研究，其三萜类和多糖等主要化学成分、药理作用及应用开发研究备受关注。对茯苓的化学成分、药理作用进行系统综述，根据质量标志物的概念，从亲缘学及化学成分特有性、传统药效、传统药性、化学成分可测性、不同加工方法的影响等几个方面对茯苓质量标志物进行预测分析，为茯苓质量评价研究和产品开发提供科学依据。

作者简介：

陈卫东 教授

安徽中医药大学中药学博士生导师。主要从事于药物代谢动力学、药剂学、道地中药材品质提升与可持续发展等方面的研究工作。

中国药理学会药物代谢专业委员会副主任委员，中国菌物协会茯苓产业分会副会长，国家药监局中药质量研究与评价重点实验室学术委员会委员。安徽省药学会常务理事，安徽省药学会药物代谢专业委员会名誉主任委员。主持国家自然科学基金面上项目2项，国家科技重大专项重大新药创制专项1项以及国家中医药管理局中药标准化项目，安徽省重大专项、中央引导地方发展专项等课题共20余项。获安徽省自然科学奖三等奖（排名第一）。在 Hepatology、Carbohydrate Polymers、DMD、APSB等期刊发表SCI收录论文70余篇（IF >10，7篇）；在《中草药》《中国药学杂志》《中国中药杂志》等中文核心期刊发表论文100余篇；授权发明专利4项；编写著作8部；申请新品种2项；制定安徽省地方标准1项。

⑦  题目：基于源头控制的中药制剂质量研究

作者：阳长明，周思源（国家药品监督管理局 药品评审中心）

摘要：中药制剂的研究设计、中药材质量、饮片炮制加工以及中药制剂生产过程控制是影响中药制剂质量的关键因素，也是中药制剂质量控制的源头。通过对中药制剂质量控制现状的分析，对《中药新药用药材质量控制研究技术指导原则（试行）》《中药新药用饮片炮制研究技术指导原则（试行）》《中药新药质量标准研究技术指导原则（试行）》3个指导原则主要内容的介绍和解读，提出基于源头控制的中药制剂质量研究思路，即重视中药制剂的研究设计，重视作为中药制剂原料的中药材质量，重视饮片炮制加工及重视制剂生产过程控制，构建符合中药特点的质量标准体系，控制中药制剂的质量。

作者简介：

阳长明  博士

主任药师，高级审评员，国家药品监督管理局药品审评中心中药民族药药学部部长，国家药典委员会委员，中华中医药学会中药制剂分会副主任委员，曾获卫生部有突出贡献中青年专家、全国科技系统抗击新冠肺炎疫情先进个人称号。

⑧  题目：水蛭冻干粉对糖尿病肾病大鼠肾组织损伤的保护作用

作者：杨帆，陈志强（河北中医学院）

摘要：目的 探讨水蛭冻干粉对糖尿病肾病大鼠肾组织损伤的保护作用。方法 SD大鼠随机选取8只作为对照组，其余大鼠给予高脂饲料喂养联合ip链脲佐菌素（35 mg/kg）建立糖尿病肾病模型，成模大鼠随机分为模型组及水蛭冻干粉低、中、高剂量（0.3、0.6、1.2 g/kg）组。给药16周后，检测大鼠24 h尿微量白蛋白（24 h urinary microalbumin，24 h-mALB）、空腹血糖、尿素氮（urea nitrogen，BUN）、肌酐（creatinine，Scr）水平和肾质量/体质量；采用TBA法和羟胺法测定大鼠血清超氧化物歧化酶（superoxide dismutase，SOD）活性和丙二醛（malondialdehyde，MDA）水平；采用ELISA法检测大鼠血清肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）、白细胞介素-1β（interleukin-1β，IL-1β）和单核细胞趋化因子-1（monocyte chemokine-1，MCP-1）水平；Western blotting法检测大鼠肾组织Janus蛋白酪氨酸激酶2/信号转导和转录激活子1、3（janus kinase 2/signal transducer and activator of transcription1、3，JAK2/STAT1/STAT3）通路相关蛋白表达。结果 与对照组比较，模型组大鼠24 h-mALB、空腹血糖、肾功能（BUN、Scr）、肾质量/体质量指标均显著升高（P<0.01），血清MDA、TNF-α、IL-1β和MCP-1水平显著增加（P<0.01），SOD活性显著降低（P<0.01），肾组织JAK2/STAT1/STAT3通路被激活（P<0.05、0.01）。与模型组比较，水蛭冻干粉组大鼠24 h-mALB排泄降低（P<0.01），肾功能（BUN、Scr）、肾质量/体质量改善（P<0.05、0.01），氧化损伤减轻（P<0.05、0.01），血清炎症因子水平下降（P<0.05、0.01），肾组织JAK2/STAT1/STAT3通路被抑制（P<0.05、0.01）。结论 水蛭冻干粉可能通过抑制糖尿病肾病大鼠氧化应激及炎症因子的产生，抑制肾组织JAK2/STAT1/STAT3信号通路活化，从而降低mALB排泄，改善肾功能，进而发挥肾脏保护作用。

作者简介：

杨帆  博士

医学博士，助理研究员，主治医师，河北中医药学会肾病专业委员会委员，主要从事慢性肾脏病的中医药治疗及其机制研究。主持和参与国家自然科学基金课题1项，河北省自然科学基金课题2项，河北省重点研发计划项目1项，河北省教育厅课题2项，河北省中医药管理局课题4项，河北省卫健委课题1项，河北中医学院博士基金课题1项，指导国家级大学生创新创业课题1项，发表SCI论文2篇，CSCD论文20余篇，科技核心2篇。

《现代药物与临床》1篇：

⑨  题目：抗生素耐药与抗生素新药开发的研究进展

作者：孙双勇，王玉丽（天津医药集团研究院）

摘要：抗生素的发现和使用是20世纪最伟大的成就之一。随着抗生素的广泛应用，抗生素耐药成为药物使用时应重点关注的问题。抗生素耐药主要与细菌的自然选择、抗生素不合理使用有关，同时也使得抗生素新药的开发存在着诸多挑战。世界卫生组织（WHO）一直关注抗生素的危害和耐药问题，认为这些问题已经成为公共卫生和可持续医疗的最严重挑战。对抗生素耐药现状、原因、机制和抗生素新药开发的研究进展进行综述，为应对抗生素耐药，需要全球医学家、企业家、各国政府和公众共同努力，相信一定可以找到解决抗生素耐药的适宜途径。

作者简介：

孙双勇 博士

研究员，津药生物科技有限公司（原天津医药集团研究总院）创新药研究中心药理室负责人，天津医科大学、天津中医药大学硕士生导师，主要研究方向为创新药的设计与临床前评价研究。近年来发表学术论文50余篇，申报专利10项，获临床批件9个；担任《中国药物评价》、《中国实验动物学报》、《中国比较医学杂志》杂志编委或青年编委；入选天津市特支计划“青年拔尖人才”、天津市科技局入库专家、天津市“创新创业创优”先进个人、天津市“131人才”等人才计划。

《药物评价研究》1篇：

⑩  题目：丹参有效成分及丹参类制剂抗炎药理作用的研究进展

作者：原景，鞠爱春（天津中医药大学）

摘要：中药在治疗炎症方面具有疗效较好、毒副作用小等优点。综述丹参Salvia miltiorrhiza中的水溶性成分（丹酚酸A、丹参茎叶总酚酸、丹酚酸B、迷迭香酸、丹参素等）、脂溶性成分（丹参酮IIA、丹参酮I、隐丹参酮、甲基丹参酮等）、丹参多糖，丹参类注射液（丹参注射液、注射用丹参多酚酸、丹红注射液等）以及丹参其他类制剂（如丹参凝胶、丹参涂膜剂等）的抗炎药理作用研究进展，以期为丹参抗炎作用研究及丹参的临床应用提供参考。

作者简介：

李德坤 研究员

天津天士力之骄药业有限公司药物警戒总监，天津市中药注射剂安全性评价企业重点实验室执行主任。2001年入职天士力集团，从事中药工艺开发、质量及标准研究、药效及安全性研究、药物警戒研究等。研究成果获得天津科技进步一等奖2项、北京科技进步一等奖1项、天津科技进步二等奖2项、协会奖项4项。发表文章186篇，20项发明专利获得授权。中国中药协会中药产品开发与培育专委会常委、中华中医药学会中药毒理学与安全性研究分会常委、《药物评价研究》编委。