[关键词]
[摘要]
中药挥发油是芳香中药所蕴含的一类挥发性成分,在抗菌、抗氧化、抗炎等方面疗效显著,但存在易挥发、易氧化降解等问题,极大影响了中成药制剂质量品质。因此,创新中药挥发油稳定化技术已成为该领域的研究热点。系统总结了中药挥发油稳定化技术的研究进展,包括环糊精包合技术、乳化技术、微囊包封技术、多孔吸附技术等,并综述了以上技术在含挥发油液体制剂、半固体制剂与固体制剂中的应用,同时简要论述了中药挥发油稳定化技术转化、成分检测与控制以及质量标准化方面存在的问题与挑战,为中药挥发油稳定技术的制剂转化应用提供参考。
[Key word]
[Abstract]
Volatile oils in traditional Chinese medicine (TCM) are a class of volatile components derived from aromatic herbs, exhibiting significant therapeutic effects in antibacterial, antioxidant, and anti-inflammatory activities. However, they are prone to volatility and oxidative degradation, which significantly affect the quality and efficacy of TCM formulations. Therefore, the development of innovative stabilization technologies for TCM volatile oils has become a research focus in this field. This paper systematically reviews the research progress in stabilization technologies, including cyclodextrin inclusion, emulsion encapsulation, microencapsulation, and porous adsorption-based methods and the application of the above technologies in liquid, semi-solid, and solid formulations containing volatile oils. Additionally, the study briefly discusses the problems and challenges in the transformation of stabilization technologies, component detection and control, and quality standardization, aiming to provide practical guidance for the formulation transformation and application of TCM volatile oil stabilization technologies.
[中图分类号]
R283
[基金项目]
国家自然科学基金资助项目(82474087);江西中医药大学研究生创新专项基金项目(XJ-S202482)