马齿苋Portulacae Herba是传统的药食兼用植物，具有清热解毒、凉血止血、止痢的功效。现代研究表明，马齿苋中主要含有黄酮、生物碱、多糖、酚酸、脂肪酸和维生素等成分，具有抗炎、抗氧化、调血脂、降尿酸、抗真菌和抗肿瘤等活性，其抗肿瘤活性主要体现在对肝癌、肺癌、宫颈癌、乳腺癌等恶性肿瘤细胞具有抑制增殖、侵袭和转移、诱导凋亡、抗氧化、调节代谢、提高机体免疫力等方面。通过对马齿苋抗肿瘤的活性成分和作用机制进行阐述，旨在揭示马齿苋活性成分发挥抗肿瘤作用的分子机制，为马齿苋抗肿瘤作用的深入研究和开发利用提供依据。

Machixian (Portulacae Herba) is a traditional medicinal and edible plant, with the effects of clearing heat and detoxifying, cooling blood and stopping bleeding and dysentery. Modern studies have shown that Portulacae Herba mainly contains flavonoids, alkaloids, polysaccharides, phenolic acids, fatty acids, vitamins and other compounds, which show anti-inflammatory, antioxidant, lipid-regulating, uric acid-lowering, antifungal and antitumor activities, and its antitumor activities are mainly reflected in the inhibition of proliferation, invasion and metastasis, induction of apoptosis, anti-oxidation, regulation of metabolism, and improvement of immunity of malignant tumor cells such as liver cancer, lung cancer, cervical cancer, breast cancer, etc. By elaborating on the active components and mechanism of Portulacae Herba against tumors, this paper aims to reveal the molecular mechanisms by which the active components of Portulacae Herba exert their anti-tumor effects, providing a basis for the in-depth research, development and utilization of the antitumor effects for Portulacae Herba.

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国家自然科学基金资助项目（82360844）；云南省科技厅资助项目（202101AZ070001-126，202101AZ070001-173）