双心疾病是心血管疾病与心理障碍共病的临床综合征，发病率居高不下，严重影响患者生活质量与远期预后。西医治疗存在药物相互作用风险、心理干预资源匮乏等局限。黄连温胆汤（Huanglian Wendan Decoction，HLWDT）出自清代《六因条辨》，具有清热化痰、和胃利胆、宁心安神之效，契合双心疾病痰热扰心的核心病机。通过系统梳理近年来HLWDT治疗双心疾病的机制研究，总结了HLWDT的活性成分及其防治双心疾病的作用机制，发现该方可通过改善免疫炎症反应、调节神经递质代谢、上调脑源性神经营养因子表达、改善氧化应激损伤、抑制下丘脑-垂体-肾上腺轴亢进等多途径发挥作用，阐明其多成分、多靶点改善冠心病、心律失常、心力衰竭、高血压等相关双心疾病的优势。为HLWDT治疗双心疾病的临床推广与深入研究提供参考。

Psycho-cardiological disease refers to a clinical syndrome involving the coexistence of cardiovascular diseases and psychological disorders. It maintains a consistently high prevalence and seriously affects patients’ quality of life as well as long-term prognosis. Treatments with Western medicine present limitations including risks of drug interactions and a shortage of psychological intervention resources. Huanglian Wendan Decoction (黄连温胆汤, HLWDT), derived from Liu Yin Tiao Bian of the Qing dynasty, has the effects of clearing heat and resolving phlegm, regulating the stomach and benefiting the gallbladder, and tranquilizing the mind. It conforms to the core pathogenesis of psycho-cardiological disease: phlegm-heat disturbing the heart. By systematically reviewing mechanistic studies on HLWDT against psycho-cardiological disease in recent years, this paper summarizes the active components of HLWDT and its mechanisms in preventing and treating psycho-cardiological disease. It is found that this prescription exerts effects through multiple pathways, such as ameliorating immune inflammatory responses, regulating neurotransmitter metabolism, upregulating the expression of brain-derived neurotrophic factor, alleviating oxidative stress injury, and inhibiting hyperactivity of the hypothalamic-pituitary-adrenal axis, thus illustrating its advantages in multi-component and multi-target improvement of related psycho-cardiological diseases including coronary heart disease, arrhythmia, heart failure and hypertension. This provides a reference for the clinical promotion and in-depth research of HLWDT in treatment of psycho-cardiological disease.

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国家自然科学基金资助项目（82374240）；广东省基础与应用基础研究基金资助项目（2024A1515013184）；陕西省重点研发计划-重点产业创新链（群）项目（2024SF-ZDCYL-03-21）；国家中医药管理局高水平中医药重点学科建设项目（zyyzdxk-2023160）；广东省中医院名中医药专家学术经验传承工作室建设项目（中医二院[2025]17号）；广东省中医院范小平科研启动经费项目（2021KT1709）