斑马鱼凭借其胚胎透明性、遗传可操作性及与哺乳动物高度保守的肝脏结构与功能，已成为肝脏疾病机制研究与药物开发的重要模式生物。通过系统综述斑马鱼在肝损伤、肝纤维化及肝细胞癌中的模型构建方法，重点探讨中药组分在改善肝损伤、抗纤维化及抗肿瘤方面的治疗作用，旨在为拓展斑马鱼模型在肝脏疾病研究中的应用及推动中药防治肝脏疾病的研究提供新思路与方法。

Zebrafish are a critical model organism for investigating liver disease mechanisms and drug discovery because of their embryonic transparency and genetic manipulability, as well as their possession of a structurally and functionally conserved liver highly homologous to mammals. This review systematically summarizes methodologies for establishing zebrafish models of liver injury, hepatic fibrosis, and hepatocellular carcinoma, and focuses on exploring the therapeutic effects of traditional Chinese medicine (TCM) components in ameliorating liver injury, counteracting fibrogenesis, and inhibiting tumorigenesis,with the aims of providing novel perspectives and methodologies for advancing the application of zebrafish models in hepatopathology research and promoting TCM-based interventions for liver diseases.

R285

国家自然科学基金项目（82460841）;甘肃省重点人才（青年团队）项目（2024QNTD36）;甘肃省自然科学基金项目（22JR11RA114）;甘肃省高校产业支撑计划项目（2024CYZC-39）;甘肃省中医药研究中心开放课题（zyzx-2023-01）;甘肃中医药大学校级创新创业项目（2026CXCY-319）