栀子豉汤首载于汉代张仲景所著伤寒论》，收录于国家中医药管理局公布的古代经典名方目录（第二批）》，是治疗“虚烦”“心中懊侬”的经典方剂。栀子豉汤组方简洁，现代药理学表明其活性成分具有镇静催眠、降糖、调节肺组织损伤、保护肝脏和心肌细胞等作用。该方主治热郁胸膈不寐证，临床多用于神经系统疾病、胃肠道疾病等。通过对栀子豉汤的药理作用、现代临床应用及现代研究等进行系统总结和分析，为栀子豉汤未来的研究和开发提供理论依据。

Zhizichi Decoction (栀子豉汤) firstly recorded in the Treatise on Febrile Diseases written by Zhang Zhongjing, was included in the Catalogue of Ancient Classical Prescriptions (second batch) published by the National Administration of Traditional Chinese Medicine, which is a classic prescription for treating “restlessness due to deficiency” and “inner distress”. The formula of ZhiziChi Decoction is simple. Modern pharmacological studies have found that the active components of Zhizichi Decoction have the effects such as sedation and sleep induction, hypoglycemic action, regulation of lung tissue damage, protection of liver and myocardial cells. This classic formula is used to treat agrypnia and annoyance with heat, clinically, it has been used for treatment of neurological disorders and gastrointestinal diseases. This paper systematically summarizes and sorts out the pharmacological effects, modern clinical applications and modern research of Zhizichi Decoction, which can provide a theoretical basis for the future research and development of ZhiziChi Decoction.

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国家自然科学基金青年基金项目（82204750）;湖北省技术创新计划重大项目（2024BCA002）