中药多糖（traditional Chinese medicine polysaccharides，TCMP）因活性丰富、安全性高、相容性好、可化学修饰等特点受到广泛关注，但由于其大分子结构、生物利用度较低、药理作用较弱，限制了其制剂开发和临床应用。纳米硒（selenium nanoparticles，SeNPs）是一种高生物活性、低毒性的单质硒，在医药、食品领域具有较大的应用潜力。将TCMP与SeNPs结合是克服二者固有的局限性（生物利用度低、稳定性差），发挥功效协同效应，获得新型候选药物的有效途径之一，已成为近年来研究的热点。通过系统归纳总结了中药多糖纳米硒（traditional Chinese medicine polysaccharide-selenium nanoparticles，TCMP-SeNPs）的制备、表征及其理化性质的影响和调控，综述了TCMP-SeNPs的生物活性、构效关系、消化吸收特性和安全性的研究进展，介绍了TCMP-SeNPs在药品、食品相关领域的应用，为TCMP-SeNPs的研发提供理论参考和研究思路。

Traditional Chinese medicine polysaccharides (TCMP) have garnered significant attention due to their rich bioactivities, high safety, good compatibility, and amenability to chemical modification. However, their large molecular structure leads to low bioavailability and relatively weak pharmacological effects, which limits their pharmaceutical development and clinical application. Selenium nanoparticles (SeNPs), a form of elemental selenium characterized by high bioactivity and low toxicity, exhibit considerable potential for applications in medicine and food. Combining TCMP with SeNPs represents an effective strategy to overcome their inherent limitations (such as low bioavailability and poor stability), leverage synergistic therapeutic effects, and develop novel drug candidates. Consequently, this approach has become a prominent research focus in recent years. This article systematically summarizes the preparation, characterization, and the influencing factors and regulation of the physicochemical properties of TCMP-SeNPs. It reviews the research progress on the bioactivities, structure-activity relationships, digestion and absorption characteristics, and safety profiles of TCMP-SeNPs. Furthermore, it introduces the applications of TCMP-SeNPs in pharmaceuticals and food related fields, aiming to provide theoretical references and research insights for the future development of TCMP-SeNPs.

R285

甘肃省教育厅高校教师创新基金项目（2024A-321）；甘肃省高等学校创新基金项目（2021A-320）；甘肃卫生职业学院2024年校级课题（202407）；甘肃省中药制药工艺工程研究中心开放课题（ZYGY202005）