传统中药作为肿瘤现代疗法的主流补充和替代疗法已被广泛接受。然而,目前很多有确切抗肿瘤疗效的中药却无法用对抗医学的思维明确其药效物质基础与作用机制。外泌体作为一种内源性物质,可参与肿瘤微环境以及其他组织、器官的相互通讯,也可作为中间媒介物质影响肿瘤治疗。系统综述了中药通过外泌体间接抗肿瘤的作用机制以及外泌体用作中药载体拓展抗肿瘤中药的临床疗效与应用,旨在基于外泌体发掘更多的抗肿瘤中药药效成分,进一步阐释中药抗肿瘤的复杂机制,推动中医药在肿瘤治疗领域的发展与应用。

Traditional Chinese medicine (TCM) has been widely accepted as the mainstream complementary and alternative therapy of modern cancer therapy. However, the material bases and action mechanisms of many TCM with exact anti-tumor efficacy could not be clearly clarified by using the antagonistic medical thinking till now. As endogenous substances, exosomes not only participate in the communication between tumor microenvironment and other tissues and organs, but also act as an intermediary substance to affect tumor therapy. Mechanisms on indirect anti-tumor action of TCM via exosomes and usage of exosomes as the carriers of TCM to expand the clinical efficacy and application of anti-tumor TCM were mainly reviewed in this paper, in order to explore more effective components and clarify the complex mechanisms of anti-tumor TCM to promote the development of TCM in the field of tumor therapy.

R282.710.5

国家自然科学基金面上项目（82174062）；国家自然科学基金面上项目（81573682）