葫芦烷型降三萜类化合物是一类结构新颖的化合物，是在葫芦烷型三萜的30个碳骨架的基础上减少1个或几个碳所得。按其缺少碳原子的位置可分为2-降（a）、3-降（b）、19-降（c）、27-降（d）、29-降（e）、19,29-降（f）、25,26,27-降（g）、24,25,26,27-降（h）、23,24,25,26,27-降（i）、22,23,24,25,26,27-降（j）、22,23,24,25,26,27,29-降（k）、20,21,22,23,24,25,26,27-降（l）共12种类型。此类化合物结构新颖多样，具有抗肿瘤、抗炎、降血糖和抗氧化等多种药理活性。对葫芦烷型降三萜类化合物的植物分布、化学结构特征以及药理活性进行系统的总结，以期为该类化合物进一步的开发与合理利用提供参考。

Nor-cucurbitacin triterpenes are a class of compounds with novel structures, which are formed by the reduction of one or several carbons on the 30 carbons skeleton of cucurbitacin-type triterpenoids. According to the position of vacant carbon atom, they could be divided into twelve types, including 2-nor (a), 3-nor (b),19-nor (c), 27-nor (d), 29-nor (e), 19,29-nor (f), 25,26,27-nor (g), 24,25,26,27-nor (h), 23,24,25,26,27-nor (i), 22,23,24,25,26,27-nor (j), 22,23,24,25,26,27,29-nor (k) and 20,21,22,23,24,25,26,27-nor (l). Moreover, nor-cucurbitacin triterpenes have various pharmacological effects, such as antitumor, anti-inflammation, antidiabetics, and anti-oxidant, etc. Plant distribution, chemical structural characteristics and pharmacological activities of nor-cucurbitacin triterpenes were systematically summarized in this paper, in order to provide a reference for further development and rational utilization of these compounds.

R282.710.5

中国医学科学院创新工程项目（2017-12M-1-013）