槲皮素属于黄酮醇类生物活性物质，具有抗抑郁、抗炎、抗氧化、抗肿瘤、抗菌、免疫抑制、神经保护等多种药理学活性。从神经保护作用、炎症反应、氧化应激、神经递质、下丘脑-垂体-肾上腺（hypothalamic-pituitary-adrenal axis，HPA）轴及神经突触可塑性等方面总结槲皮素的抗抑郁作用机制。此外，从槲皮素糖苷衍生物角度总结了异槲皮苷、金丝桃苷、芦丁、槲皮素4′-O-葡萄糖苷、槲皮素-3-α-L-阿拉伯呋喃糖苷等抗抑郁活性，以期为今后槲皮素及其糖苷衍生物抗抑郁的进一步研究以及为药物开发和应用提供思路。

Quercetin is a flavonoid bioactive substance with many pharmacological activities such as anti-depression, anti- inflammation, anti-oxidation, anti-tumor, anti-microbial, immunosuppression and neuroprotection. The antidepressant mechanism of quercetin from the aspects of neuroprotection, inflammation, oxidative stress, neurotransmitter, HPA axis and neurosynaptic plasticity are summarized in this paper. In addition, the antidepressant activities of isoquercitrin, hyperin, rutin, quercetin 4'-O-glucoside and arabinofuran glycoside are summarized from the perspective of quercetin glycoside derivatives. It is expected to provide ideas for further antidepressant research and drug development and application of quercetin in the future.

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国家“重大新药创制”科技重大专项（2017ZX09309026）；国家自然科学基金资助项目（82174357）；国家自然科学基金资助项目（82104836）；湖南省自然科学基金资助项目（2019JJ50428）；湖南省研究生创新项目（CX20200763）；湖南中医药大学校级科研基金资助项目（2020XJJJ007）