目的 研究分心木Diaphragma Juglandis Fructus的化学成分。方法 采用正相硅胶、反相ODS、中压制备液相色谱和制备型高效液相色谱等多种色谱技术和手段进行分离和纯化，通过1D和2D-NMR、HR-ESI-MS等谱学数据分析鉴定化合物结构。结果 从分心木中共分离得到5个脂肪酸类成分，分别鉴定为胡桃酸酯A（1）、胡桃酸酯B（2）、pinellic acid（3）、(Z)-11R,12S,13S-trihydroxy-9-octadecenoate（4）和9S,12S,13S-三羟基十八烷-10E,15Z-二烯酸（5）。结论 化合物1和2为新的脂肪酸酯类化合物，化合物3～5为首次从胡桃中分离得到。

Objective To study the chemical constituents from Diaphragma juglandis Fructus. Methods The chemical constitutes were isolated and purified by silica gel, ODS, preparative MPLC and preparative HPLC. Their structures were elucidated based on 1D-NMR, 2D-NMR, and HR-ESI-MS. Results Five fatty acids compounds were isolated and identified from Diaphragma juglandis Fructus. The structures of 1 and 2 were established and named juglans acid ester A (1) and juglans acid ester B (2), respectively. The other compounds were identified as pinellic acid (3), (Z)-11R,12S,13S-trihydroxy-9-octadecenoate (4), and 9S,12S,13S-trihydroxy-octadeca-10E,15Z-dienoic acid (5). Conclusions Compounds 1 and 2 are new fatty acid esters. Compounds 3-5 are isolated from Juglans regia for the first time.

R284.1

山西省卫生健康委科研项目（2020094）；基于炎性反应的重大疾病创新药物山西省重点实验室开放基金资助项目（2021sxcxyw10）；中央引导地方科技发展资金项目（YDZX20201400001518）