目的 采用灰色关联-TOPSIS法对不同产地山楂质量进行评价。方法 建立高效液相色谱波长切换法同时测定山楂药材中绿原酸、表儿茶素、金丝桃苷、异槲皮苷、芦丁、槲皮素、牡荆素、牡荆素葡萄糖苷和牡荆素鼠李糖苷9种成分含量，并采用灰色关联-TOPSIS法进行分析，对收集的湖北、安徽、河北、山东、河南、山西、陕西7个产地山楂进行质量评价。结果 建立含量测定方法快速、灵敏、准确，通过灰色关联-TOPSIS分析表明，山东、河南、安徽产地的山楂质量较优。结论 该方法为山楂药材的质量控制和评价以及中药新药研究过程中山楂产地的选择提供依据。

Objective To comprehensively evaluate the quality of Shanzha (Crataegi Fructus) from different origins by grey correlation-TOPSIS method. Methods HPLC wave-length switching method was established to determine the components of chlorogenic acid, epicatechin, hypericin, isoquercetin, rutin, quercetin, vitexin, vitexin glucoside and vitexin rhamnoside. The grey correlation-TOPSIS method was used to analyze the results. The quality of the collected Crataegi Fructus from seven producing areas in Hubei, Anhui, Hebei, Shandong, Henan, Shanxi and Shaanxi was evaluated. Results The HPLC method was rapid, sensitive and accurate. The results of grey correlation-TOPSIS analysis showed that the quality of Crataegi Fructus from Shandong, Henan and Anhui origins was better. Conclusion The method provides the basis for the quality control and evaluation of Crataegi Fructus and the selection of Crataegi Fructus producing area in the research of new Chinese medicine.

R282.6

国家工信部智能制造综合标准化与新模式应用项目（KYYY20170820）；国家重大新药创制科技重大专项（2018ZX09201010-004）；中医药科学技术研究专项：数字化中药配方颗粒产业化关键技术研究