[关键词]
[摘要]
膝骨性关节炎（knee osteoarthritis，KOA）是一种以关节软骨被破坏及软骨下骨重塑为主要病理改变的退行性骨关节疾病，主要表现为膝关节的疼痛与功能受限，严重影响患者的生活质量，对患者及社会产生巨大的医疗负担。至今其发病机制尚不完全清楚。Wnt信号转导的活化与KOA发病机制密切相关，而当前对Wnt信号通路的研究侧重于Wnt/β-连环蛋白（Wnt/β-catenin）信号通路及其激活或抑制蛋白的表达。近年来，利用中药通过调控Wnt/β-catenin信号通路治疗KOA的机制被大量研究。综述近年来中药单体及中药复方调控Wnt/β-catenin信号通路治疗KOA的成果，进一步为临床运用中药治疗KOA提供相关基础研究。
[Key word]
[Abstract]
Knee osteoarthritis (KOA) is a degenerative osteoarthritis with destruction of articular cartilage and remodeling of subchondral bone as the main pathological changes. It is mainly manifested as pain and function limitation of knee joint, which seriously affects patient's quality of life and causes huge medical burden to patients and society. Up to now, its pathogenesis is not fully understood. The activation of Wnt signal transduction is closely related to the pathogenesis of KOA, and the current research on Wnt signaling pathway focuses on the Wnt/β-catenin signaling pathway and its activation or inhibition protein expression. In recent years, a large number of studies have been conducted on mechanism of traditional Chinese medicine in treatment of KOA by regulating Wnt/β-catenin signaling pathway. The recent achievements in the regulation of Wnt/β-catenin signaling pathway by traditional Chinese medicine monomers and traditional Chinese medicine compounds in treatment of KOA are reviewed in this paper, in order to provide basic research for the clinical application of traditional Chinese medicine in treatment of KOA.
[中图分类号]
R285
[基金项目]
国家自然科学基金资助项目（82074470）；国家自然科学基金资助项目（81673994）；国家自然科学基金资助项目（81873316）；国家自然科学基金资助项目（51573137）；天津市教委科研计划项目（2019KJ064）；王平劳模创新工作室-天津市教委资助项目（2016-3）；中医传承工作室-天津卫计委资助项目（2017-193）
