目的 研究迷迭香Rosmarinus officinalis中的酚酸类化学成分。方法 迷迭香叶用80%乙醇提取，碱溶酸沉处理后，经硅胶柱色谱、聚酰胺柱色谱、亲脂性Sephadex LH-20柱色谱、重结晶等手段进行分离纯化，并结合多种波谱方法进行结构鉴定。结果 从迷迭香叶80%乙醇提取物中分离得9个酚酸类成分，包括一系列松香烷二萜类化合物，分别为7β-乙氧基迷迭香醌（1）、7-乙酰氧基香茶菜酚A（2）、鼠尾草酚（3）、迷迭香酚（4）、表迷迭香酚（5）、异迷迭香酚（6）、20-去氧鼠尾草酚（7）、木香醌酸（8）、桦木酸（9）。结论 化合物1和2为新化合物。

Objective To study the phenolic acids of Rosmarinus officinalis. Methods The compounds were isolated and purified from the 80% ethanol extract of leaves of R. officinalis after a process of alkali-solution and acid-isolation by several methods including silica gel column chromatography, polyamide column chromatography, lipophilic Sephadex LH-20 column chromatography, recrystal, et al. And their structures were elucidated on the basis of spectral data. Results Nine phenolic acids were isolated and identified as 7β-ethoxy rosmaqunione (1), 7-acetoxy atuntzensin A (2), carnosol (3), rosmanol (4), epirosmanol (5), isorosmanol (6), 20-deoxocarnosol (7), royleanonic acid (8) and betulinic acid (9). Conclusion Compound 1 and 2 are new compounds.

R284.1

国家自然科学基金资助项目（81573314）