知母宁是一种具有C-糖苷和氧杂蒽酮成分的天然化合物，具有抗氧化、抗炎性损伤、提高线粒体生物能量和改善认知缺陷等多种生物活性，可以通过血脑屏障在中枢神经系统中发挥神经保护作用。对知母宁在神经退行性疾病中的作用及机制研究进展进行综述，以此探究其发挥神经保护作用的潜在分子机制，为其进一步的研究和应用提供参考。

Chinonin is a natural compound with C-glycoside and xanthones, possessing several biological effects, such as anti-oxidation, anti-inflammation, improving mitochondrial bioenergy and ameliorating cognitive deficits. Moreover, chinonin can exert its neuroprotective effect on the central nervous system through the blood-brain barrier. This review discusses the pathophysiological mechanisms of Alzheimer's disease and Parkinson's disease in neurodegenerative diseases, for the purpose of investigating the underlying mechanisms of chinonin in neuroprotection and providing the reference for its further research and application.

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国家自然科学基金资助项目（81473376）；北京中医药大学科研纵向发展基金项目（2019-ZXFZJJ-074）