激烈的市场竞争,使得经典方剂二次开发,尤其是针对已有中成药进行的二次开发,成为许多制药企业研发重点。在经典方的二次开发中,药物代谢动力学将成为一个重要的手段。目前我国对经典方的药动学研究主要集中在解释方剂配伍的合理性,以及指导临床用药这两方面上,较少的以此为突破口进行经典方的二次开发。尝试从中药、天然药物新药分类的角度,浅析药动学在经典方二次开发中的应用,以探寻可以申报新药的可能性。

Under fierce market competition,the secondary development of classical prescription on Chinese materia medica(CMM),especially on Chinese patent medicine has become the research and development key project of many pharmaceutical companies.In the secondary development of classical prescription on CMM,pharmacokinetics will become an essential method.At present,pharmacokinetics of the classical prescription mainly focuses on the explanation of the reasonable compatibility,as well as guidance on the clinical application,less as a starting point for a secondary development of classical prescripion.From the perspective of new drug classification of CMM and natural medicine,the application of pharmacokietics in the secondary development of classical prescription on CMM has been analyzed in this paper,in order to explore the new drugs.

江苏省高校自然基金重大基础研究资助项目(06KJA36022);江苏省高校“青蓝工程”科技创新团队建设项目资助;江苏省方剂研究重点实验室开放课题(022021014006)