系统性解析中药活性单体的抗炎调控机制，是当前中医药科研领域的难点之一。而多组学联合分析技术通过多维度的解析策略，可系统性阐释中药抗炎活性单体干预炎症性疾病的关键生物标志物、作用途径及不同维度间的生物标志物的调控网络，为其抗炎机制的研究提供了创新方案。系统梳理了当前多组学分析技术的核心方法、多组学联合分析技术在中药抗炎活性单体机制研究中的实际应用及前沿的多组学联合分析策略，并探讨了多组学联合分析技术在研究中药活性单体抗炎机制时存在的问题以及潜在处理问题的方法，为中药抗炎活性单体的机制研究与开发利用提供新的视角，促进中药现代化研究的进一步发展。

Systematic elucidation of the anti-inflammatory regulatory mechanisms of bioactive monomers derived from traditional Chinese medicine (TCM) remains one of the key challenges in the current field of TCM research. However, multi-omics integrated analysis, employing multi-dimensional strategies, can comprehensively elucidate the key biomarkers, signaling pathways, and regulatory networks involved in the intervention of TCMs anti-inflammatory monomers in inflammatory diseases, thereby offering an innovative approach to studying their anti-inflammatory mechanisms. This study systematically reviews core methods in multi-omics analysis, practical applications of multi-omics integrated analysis in probing the mechanisms of anti-inflammatory active monomers in TCM, and the latest advances in multi-omics combined analysis strategies. Furthermore, we critically examine the issues encountered in studying the anti-inflammatory mechanisms of TCM active monomers using multi-omics technologies and propose strategies to address these challenges. This work aims to offer fresh perspectives for studying the mechanisms and optimizing the utilization of anti-inflammatory active monomers in TCM, ultimately advancing TCM modernization research.

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国家自然科学基金资助项目(82204590);国家自然科学基金资助项目(82560758); 江西省自然科学基金资助项目(20224BAB216099,20252BAC240467); 中国博士后科学基金第七十三批面上资助(2023M731439); 江西省研究生创新专项资金项目(YC2024-S754)