白藜芦醇（resveratrol，RES）是1种天然多酚类化合物，广泛存在于葡萄‌Vitis vinifera、花生Arachis hypogaea和虎杖Polygonum cuspidatum等植物中，具有抗氧化、抗炎和抗肿瘤等多种生物活性。放射治疗（radiotherapy，RT）是一种使用高能射线或粒子束来治疗疾病的手段，其凭借非侵入性治疗方式以及高精度的定位，是目前治疗癌症的重要手段之一，但放疗受限于正常组织损伤、肿瘤抵抗性和安全性。近年来，研究发现白藜芦醇可以通过调节肿瘤细胞周期、诱导凋亡和抑制DNA修复等方式提高放疗疗效，同时其抗炎和抗氧化等生物活性可减轻放疗对正常组织的不良反应。总结了白藜芦醇联合放疗的增效减毒作用及其分子机制，并探讨其临床应用前景及挑战。

Resveratrol (RES) is a naturally occurring polyphenol compound widely found in plants such as ‌Vitis vinifera, Arachis hypogaea, and Polygonum cuspidatum. It exhibits a variety of biological activities, including antioxidant, anti-inflammatory, and antitumor properties. Radiotherapy (RT), a treatment modality employing high-energy rays or particle beams, is a crucial approach for cancer therapy due to its non-invasive nature and high-precision targeting. However, RT is limited by normal tissue damage, tumor resistance, and safety concerns. Recent studies have demonstrated that RES can enhance the efficacy of RT by modulating tumor cell cycle progression, inducing apoptosis, and inhibiting DNA repair. Simultaneously, its anti-inflammatory and antioxidant activities can mitigate the toxic side effects of RT on normal tissues. This review summarizes the synergistic and detoxifying effects of RES in combination with RT, elucidates the underlying molecular mechanisms, and discusses its clinical application prospects and challenges.

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上海卫生健康委员会领军人才计划（2022LJ019）；国家自然科学基金面上项目（82473233，82272742）；长海医院“固海”计划（GH145-33）