多囊卵巢综合征（polycystic ovary syndrome，PCOS）是女性中较为常见的生殖内分泌疾病，且临床异质性高。PCOS的病因是多方面的，包括遗传易感性、环境影响、生活方式及内分泌代谢失调等。近年研究表明，生物钟在PCOS发生发展中扮演着重要角色，尤其是在线粒体功能、肠道菌群、炎症反应、脂肪组织功能等生理过程的调控方面。中药单体、中药复方及针刺疗法可通过调控生物钟改善PCOS的临床症状。通过对生物钟与PCOS的关系及中医药通过调控生物钟防治PCOS的研究进行总结，为该病临床诊治提供新的思路与方法。

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder among women, with high clinical heterogeneity. The causes of PCOS are multifaceted, including genetic susceptibility, environmental influences, lifestyle factors, and endocrine metabolic disorders. In recent years, studies have found that the biological clock plays an important role in the occurrence and development of PCOS, especially in the regulation of physiological processes such as mitochondrial function, gut microbiota, inflammatory response, and adipose tissue function. Traditional Chinese medicine (TCM) monomers, TCM compound prescriptions, and acupuncture therapy can regulate the biological clock and improve the clinical symptoms of PCOS. This article summarizes the relationship between the biological clock and PCOS, as well as the research on TCM treating PCOS by regulating the biological clock, which aims to provide new ideas and methods for the clinical diagnosis and treatment of this disease.

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国家自然科学基金资助项目（82305366）；上海市卫健委临床研究专项（20224Y0384）；上海市卫生健康委员会中医药科研项目（2024QN060）