高血压是全球重大慢性非传染性疾病，其复杂的发病机制涉及多系统功能失调。传统研究模型如二维细胞培养和动物模型在精确模拟人类生理病理过程方面存在局限，尤其难以完整阐释中医药多成分、多靶点、整体调节的复杂作用机制。类器官技术作为一种新兴三维细胞培养平台，能高度模拟人体器官的微结构、细胞组成与功能，为高血压病理生理研究和药物开发提供创新工具。通过系统阐述类器官技术在高血压及相关器官模型构建的最新进展，分析其如何弥补传统方法的不足，并重点探讨类器官在中医药防治高血压研究中的独特应用价值，为提升中医药在该领域的影响力与转化应用提供科学依据。

Hypertension is a major global chronic non-communicable disease characterized by a complex pathogenesis involving dysfunction across multiple physiological systems. Traditional research models, such as two-dimensional cell cultures and animal models, face limitations in accurately simulating human physiological and pathological processes. These models are particularly unable to fully elucidate the intricate mechanisms of traditional Chinese medicine (TCM), which features multiple components, multiple targets, and holistic regulatory effects. Organoid technology, as an emerging three-dimensional cell culture platform, can highly simulate the microarchitecture, cellular composition, and functions of human organs. This technology provides a novel and powerful tool for investigating the pathophysiology of hypertension and for advancing drug discovery. This article aims to provide a comprehensive overview of recent advances in the development of hypertension-related organoid models, evaluate how these models address the limitations of conventional approaches, and highlight the unique potential of organoids in advancing TCM research for prevention and treatment of hypertension. It aims to provide a scientific basis for enhancing the influence and translational application of TCM in this field.

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天津中医药大学第一附属医院“拓新工程”基金科研课题（院2023004）；天津市教委科研计划项目（2024KJ036）；国家重点研发计划（2019YFC1710005）