目的 分析2000—2025年中医药防治亚健康的研究现状，并探讨研究热点与前沿趋势，为今后的研究提供参考和方向。方法 检索中国知网、万方数据、中国生物医学文献数据库、中华医学期刊全文数据库、Web of Science核心合集数据库中2000—2025年关于中医药防治亚健康的相关文献，运用CiteSpace软件对其机构、作者、关键词等进行可视化分析。结果 共纳入中文文献2 372篇，英文文献375篇。年发文量呈波动趋势，中文文献发表量远多于英文；发文量最多的中英文期刊分别是《中国中医药现代远程教育》和Evidence-based Complementary and Alternative Medicine；发文量最多、中心性最高的机构为北京中医药大学；中、英文文献作者发文量最多的分别是罗仁和Wang Qi；关键词显示，中医体质、中医干预、体质辨识等为该领域的热点研究内容。结论 在国家自然基金重点项目和重点研发计划的推动下，以北京中医药大学为首的高校和科研机构对中医药防治亚健康展开了大量研究。目前中医药防治亚健康的研究热点集中在中医体质与亚健康的关系，亚健康的分类、评估和辨识，亚健康的症状及其中医干预方式等。未来可向亚健康与体质学说理论整合构建、创新亚健康诊断评估路径、加强症状与亚健康关联性、深化亚健康的中医疗法验证与治疗策略、大数据和人工智能助力等方面进行该领域的深化研究。

Objective This study aims to gain insight into the research landscape of traditional Chinese medicine (TCM) applications in sub-health management from 2000 to 2025 via bibliometric methods. It seeks to identify key research areas and emerging trends, with the goal of offering guidance and pointers for future investigations. Methods Literature focusing on TCM-based prevention and treatment of sub-health, published between 2000 and 2025, was collected from databases including CNKI, Wanfang Data, Chinese Biomedical Medical Database, Chinese Medical Association Journal Database, and Web of Science Core Collection. The CiteSpace tool was employed to conduct visual analyses of elements such as research institutions, authors, and keywords. Results A total of 2 372 Chinese articles and 375 English articles were included in the analysis. Annual publication output exhibited a variable pattern, with a significantly larger volume of Chinese literature compared to English. The journals with the highest number of relevant publications were Chinese Medicine Modern Distance Education and Evidence-based Complementary and Alternative Medicine. Beijing University of Chinese Medicine stood out as the institution with the highest publication count and centrality. The authors with the highest number of publications in Chinese and English literature are Luo Ren and Wang Qi, respectively. Keyword analysis revealed that TCM constitution, TCM intervention approaches, and constitution identification are key research topics in this field. Conclusion Under the impetus of initiatives like the Key Program of the National Natural Science Foundation of China and the National Key Research and Development Program, universities and research institutions spearheaded by Beijing University of Chinese Medicine—have carried out substantial research on TCM in sub-health prevention and treatment. Current research primarily centers on the link between TCM constitution and sub-health, sub-health classification, assessment and identification, sub-health symptoms, and corresponding TCM intervention strategies. Future advancements in this field could be pursued through efforts such as integrating sub-health and constitution theory, innovating sub-health diagnosis and evaluation pathways, strengthening research on symptom-sub-health correlations, deepening the validation of TCM therapies and treatment protocols for sub-health, and harnessing big data and artificial intelligence technologies.

G350;R285

中国中医科学院基本科研业务费自主选题项目（zz13-026）