抗氧化是通过清除活性氧、提升金属离子螯合能力、激活内源性抗氧化酶系统、调控抗氧化信号通路、修复氧化损伤的生物分子等方式保护机体免受氧化损伤的。抗氧化不仅是维持细胞健康的基础,还对预防疾病和延缓衰老具有关键作用。研究发现红芪Hedysari Radix中的多糖类、黄酮类化合物可以通过“清除-提升-激活-调控-修复”五联机制发挥抗氧化作用。但现有文献对红芪抗氧化作用机制的系统性总结相对较少,基于此,通过梳理整合红芪活性成分及其抗氧化作用机制,为红芪抗氧化作用的深入探讨和有效成分的进一步开发利用提供科学思路和理论依据。

Antioxidation protects the body from oxidative damage by scavenging reactive oxygen species, enhancing metal ion chelation capacity, activating endogenous antioxidant enzyme systems, regulating antioxidant signaling pathways, and repairing oxidatively damaged biomolecules. Antioxidation not only underpins cellular health but also plays a crucial role in disease prevention and delaying aging. Research indicates that polysaccharides and flavonoids in Hongqi (Hedysari Radix) exert antioxidant effects through a five-step mechanism: scavenging, enhancing, activating, regulating, and repairing. However, existing literature offers relatively few systematic summaries of the antioxidant mechanisms in Hedysari Radix. Therefore, by systematically reviewing and integrating the active components of Hedysari Radix and their antioxidant mechanisms, this study aims to provide scientific insights and theoretical foundations for in-depth exploration of its antioxidant effects and further development and utilization of its active constituents.

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国家自然科学基金资助项目（81860683）；国家自然科学基金资助项目（82160730）；国家自然科学基金青年科学基金项目（82104345）；甘肃省教育厅双一流重大科研项目（GSSYLXM-05）；甘肃省科技计划项目（21Y5FA133）