目的 低灌注性脑梗死(hypoperfusion cerebral infarction,HCI)是脑梗死的重要亚型,其当前治疗方案存在一定局限性。通过整合多源异构数据库及测量网络模块距离的方法为参麦注射液(Shenmai Injection,SMI)治疗HCI提供证据支持。方法 采用3种不同的方法在开源数据库中获取HCI的疾病靶点。通过在蛋白质互作网络中比较SMI、常规化学药、中成药与疾病靶点的S_AB、Z值,探索SMI治疗HCI的潜力;通过“靶点-成分-中药”路径,结合PageRank与Hscore方法验证SMI药物组成在治疗HCI中药推荐中的排名情况。结果 与常规化学药相比,治疗脑梗死的中成药S_AB、Z值普遍较小;与其他中成药相比,SMI的S_AB值在疾病靶点整合方法2(数据集2、数据集3)中排名靠前,在其余疾病靶点整合方法中的距离优势未凸显出来。687味中药推荐排名结果发现,在整合的4个不同的数据集中,红参排名均排在前20名,麦冬排名在前302名以内。结论 SMI可能在治疗HCI尤其是慢性心系疾病导致的HCI方面具有一定优势。其作用机制除了直接促进脑组织修复和再生外,还涉及流体剪切应力与动脉粥样硬化通路,可能与通过改善心脏泵血能力而间接达到增加脑灌注的作用有关。

Objective Hypoperfusion cerebral infarction (HCI) represents a critical subtype of cerebral infarction, for which current therapeutic strategies exhibit notable limitations. To provide evidence supporting Shenmai Injection (SMI, 参麦注射液)’s efficacy in HCI treatment by integrating multi-source heterogeneous databases and employing network module distance measurement methodologies. Methods Disease targets for HCI were identified using three distinct approaches in open-source databases. The therapeutic potential of SMI was evaluated by comparing its S_AB and Z-scores with those of conventional Western drugs and Chinese patent medicines within a protein-protein interaction network, followed by validation of SMI’s prioritized ranking in HCI treatment through a “target-component-herb” pathway analysis integrating PageRank and Hscore algorithms. Results Compared to conventional Western drugs, Chinese patent medicines for cerebral infarction showed generally lower S_AB and Z-values. Compared with other Chinese patent medicines, SMI demonstrated superior performance (lower S_AB values) in two target-integration methods (Datasets 2 and 3), though this advantage was not consistently observed across all analytical approaches. Among 687 herbs analyzed, Hongshen (Ginseng Radix et Rhizoma Rubra) consistently ranked top 20 in all four datasets, while Maidong (Ophiopogonis Radix) appeared within the top 302. Conclusion SMI may offer particular therapeutic advantages for HCI, especially in cases secondary to chronic cardiac conditions. Its mechanism appears multifactorial, involving not only direct neurorestorative effects but also modulation of fluid shear stress and atherosclerosis pathways, potentially mediated through improved cardiac output and subsequent cerebral perfusion enhancement.

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中央级公益性科研院所基本科研业务费专项资金资助（ZZ1718-XRZ-105-SJ）；中国中医科学院科技创新工程（CI2021A05042）