皮肤疾病作为慢性炎症性疾病，常伴随皮肤屏障功能障碍及异常免疫激活，严重时可进展为系统性并发症。多以糖皮质激素、免疫抑制剂等进行治疗，易引发耐药性，治疗效果不佳。甘草酸作为天然活性成分，凭借其多靶点抗炎、免疫调节及抗氧化特性，为皮肤疾病治疗提供了新思路。中医理论强调“内外同治”，甘草酸复方制剂可通过系统性调节免疫稳态与局部微环境修复协同作用，重塑皮肤“免疫-屏障”动态平衡，因此对于甘草酸的研究有助于为靶点药物的开发提供理论基础。通过对不同皮肤疾病中甘草酸免疫调节的机制进行总结，为新型靶向治疗皮肤疾病药物的开发和疫苗防控策略的制备提供理论基础。

Skin diseases, as chronic inflammatory conditions, are often accompanied by impaired skin barrier function and abnormal immune activation. In severe cases, the disease may progress to systemic complications. Treatment typically involves glucocorticoids and immunosuppressants, which can easily lead to drug resistance and suboptimal therapeutic outcomes. Glycyrrhizic acid, a natural active ingredient, offers a novel approach to dermatological treatment due to its multi-targeted anti-inflammatory, immunomodulatory, and antioxidant properties. The theory of traditional Chinese medicine emphasizes “simultaneous internal and external treatment”. Compound glycyrrhizic acid formulations synergistically restore the skin’s “immune-barrier” dynamic equilibrium by systemic immune homeostasis regulation and local microenvironment repair. Consequently, glycyrrhizic acid research provides a theoretical foundation for developing targeted drugs. By summarizing the immunomodulatory mechanisms of glycyrrhizic acid across various skin diseases, this work establishes a theoretical foundation for developing novel targeted therapies and vaccine prevention strategies against skin disorders.

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西北民族大学中央高校基本科研业务费资金项目（31920250053）；西北民族大学大学生创新创业训练计划项目（X202410742290）