酸枣仁Ziziphi Spinosae Semen作为重要的药食同源中药，具有养心安神、敛汗生津的功效，在治疗失眠方面应用广泛。通过查阅国内外相关文献资料，借助文献计量学系统分析酸枣仁治疗失眠的研究现状、热点及发文趋势，国家合作趋势，对酸枣仁通过调节单胺类神经递质、氨基酸类神经递质、下丘脑-垂体-肾上腺轴功能、调控细胞因子等治疗失眠的机制进行总结，同时对酸枣仁在保健食品、医药、化工等领域中的研发与应用进行总结，为拓宽酸枣仁的应用领域提供参考。

As a significant traditional Chinese medicine of homology of medicine and food, Suanzaoren (Ziziphi Spinosae Semen) possesses the therapeutic effects of nourishing the heart to tranquilize the mind and calm the spirit and astringing sweat to generate body fluids, and is widely employed in insomnia treatment. By reviewing relevant domestic and international literature, this review employs bibliometric analysis to systematically examine the current research status, hotspots, publication trends, and international collaboration patterns regarding Ziziphi Spinosae Semen in insomnia treatment. Furthermore, this paper summarizes the mechanisms by which Ziziphi Spinosae Semen treats insomnia, including its regulation of monoamine neurotransmitters, amino acid neurotransmitters, the function of the hypothalamic-pituitary-adrenal axis, and the modulation of cytokines. Simultaneously, the research, development, and applications of Ziziphi Spinosae Semen in various fields such as health foods, pharmaceuticals, and the chemical industry, providing insights for expanding the scope of its potential applications.

R285

天津市科技计划项目（23ZGCXQY00060）