目的 通过Meta分析探讨枇杷清肺饮治疗痤疮的安全性与有效性。方法 检索中国知网（CNKI）、维普资讯中国期刊服务平台（VIP）、万方数据知识服务平台（Wanfang）、中国生物医学文献服务系统（SinoMed）、中华医学期刊全文数据库（Yiigle）、PubMed、Web of Science Core Collection、中国临床试验注册中心（ChiCTR）、国际传统医学临床试验注册平台（ITMCTR）。检索时限为各数据库建立至2025年1月13日。检索枇杷清肺饮治疗痤疮相关临床试验，对枇杷清肺饮改善痤疮综合分级系统（global acne grading system，GAGS）评分以及痤疮相关性激素水平进行Meta分析，Egger检验评估发表偏倚，应用剪补法后进行敏感性分析。结果 共纳入24项研究，枇杷清肺饮能显著改善痤疮患者的GAGS评分（SMD＝−0.635 7, 95% CI [−0.852 2, −0.419 1], P＝0.000 2, I²＝31.8%），显著降低女性痤疮患者睾酮水平（SMD＝−0.510 0, 95% CI [−0.870 6, −0.149 3], P＝0.015 0, I²＝54.7%），提高雌二醇水平（SMD＝1.079 5, 95% CI [0.370 6, 1.788 4], P＝0.009 8, I²＝89.2%），而对皮肤病生活质量指数、卵泡刺激素与黄体生成素水平未见明显影响。不良事件发生率与对照组相比无显著差异。结论 枇杷清肺饮能降低GAGS评分，并调节痤疮相关性激素水平，临床用于治疗痤疮有较好的疗效。

Objective To reveal the safety and efficacy of Pipa Qingfei Decoction (PPQFD, 枇杷清肺饮) in treating acne based on meta-analysis. Methods CNKI, VIP, WANGFANG, SinoMed, Yiigle, PubMed, Web of Science Core Collection, ChiCTR, and ITMCTR were screened from inception to Jan 13th, 2025. Controlled trials regarding PPQFD for treating acne were searched. Meta-analysis was utilized to pool the effect of PPQFD on global acne grading system (GAGS) score and acne related hormones. Egger test was applied to assess publication bias, and leave-one-out method was utilized for sensitivity analysis. Results Twenty-four studies were included. PPQFD can alleviate GAGS score (SMD = −0.635 7, 95% CI [−0.852 2, −0.419 1], P = 0.000 2, I² = 31.8%), down-regulate the testosterone level in female participants (SMD = −0.510 0, 95% CI [−0.870 6, −0.149 3], P = 0.015 0, I² = 54.7%), and up-regulate the estradiol level (SMD = 1.079 5, 95% CI [0.370 6, 1.788 4], P = 0.009 8, I² = 89.2%), while the level of dermatology life quality index, follicle-stimulating hormone, and luteinizing hormone were not influenced. The incidence rate of adverse events showed no significant difference compared with the control group. Conclusion PPQFD can alleviate GAGS score, and regulate the level of acne related hormones, down-regulating testosterone level, which is efficacious in treating acne.

R285.64

经方与现代中药融合创新全国重点实验室开放课题（LSLSKL 20240130）