抑郁症作为一种多维度病理异质性疾病，其病理机制与线粒体功能障碍引发的能量代谢紊乱密切相关，尤见疲劳、动力缺失等核心症状。中医认为“郁证”本质在于五脏气机失调，而现代研究发现，线粒体作为细胞能量枢纽，其质量控制系统（mitochondrial quality control system，MQCS）主导的“能量代谢-氧化还原-免疫稳态”级联反应，与中医“气”的功能高度契合。MQCS失衡会破坏“气血-脏腑-神志”动态平衡，从而在分子层面阐释“气机失调”致郁的病理基础，为“调和五脏”抗抑郁治则提供科学依据。通过整合多源数据库，应用CiteSpace软件与系统药理学方法，构建MQCS动态监测体系，解析中药复方调控线粒体功能的时空网络作用，揭示其多级联反应机制。创新性地将中医抽象思维转化为可量化的参数体系，搭建了从“宏观辨证”到“微观适配”的转化桥梁，为精准医学框架下的个体化诊疗提供可操作化的方法学基础，同时为中西医整合医学的迭代升级奠定理论基石。

Depression is a multi-dimensional pathological heterogeneous disease. The pathological mechanism of depression closely relates to the disorder of energy metabolism that caused by mitochondrial dysfunction, especially in core symptoms such as fatigue, lack of motivation, etc. In traditional Chinese medicine (TCM) theory, it believes that the essence of ‘depression syndrome’ lies in the dysregulation of qi movement of Five Zang organs. Modern researches have demonstrated that mitochondrion serves as the energy hub of cells, and its “energy metabolism-redox-immune homeostasis” cascade reaction that led by mitochondrial quality control system (MQCS) is highly consistent with the function of qi in TCM theory. The imbalance of MQCS destroys the dynamic balance of “qi-blood-Zang-Fu organs-mental activity”, explaining the pathological basis of depression that caused by “dysregulation of qi movement” at the molecular level, and providing scientific evidence for anti-depression treatment principle of “harmonizing the five internal organs”. By integrating multi-source databases, applying CiteSpace software and systems pharmacology methods to construct the MQCS dynamic monitoring system and analyze the spatio-temporal network functions of TCM prescriptions in regulating mitochondrial functions, and reveal its multi-cascade reaction mechanisms. It innovatively transforms the abstract thinking of TCM into a quantifiable parameter system. A transformation bridge from “macro syndrome differentiation”to “micro adaptation”, providing an operable methodological basis for individualized diagnosis and treatments under the framework of precision medicines, and laying a theoretical foundation for the iterative upgrading of integrated Chinese and Western medicines.

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国家自然科学基金资助项目（82274360）；山西省中医药管理局资助项目（2024ZYY2A032）；2022年度山西省基础研究计划（自由探索类）项目（202203021221030）；山西省回国留学人员科研资助项目（2022-026）；山西省中医药创新团队（zyytd2024020）