帕金森病（Parkinson’s disease，PD）非运动症状涉及嗅觉减退、快速眼动睡眠行为障碍、情绪异常、认知障碍及自主神经功能紊乱等多维表现，可发生于疾病前驱期及进展期，其发生发展与α-突触核蛋白（alpha-synuclein，α-syn）异常折叠、聚集、清除障碍及朊病毒样传播密切相关。刺五加具有益气健脾、补肾安神等功效，现代药理研究显示其多成分、多靶点和多通路调节特点与α-syn病理级联的复杂性具有较高契合度。围绕α-syn病理级联，通过系统梳理α-syn生理构象动态、病理转化基础、聚集驱动因素、细胞稳态失衡及中枢神经环路损伤机制，进一步分析刺五加通过改善氧化应激、神经炎症、蛋白清除障碍、神经递质失衡及脑-肠轴异常等α-syn病理相关微环境，间接影响α-syn异常积累及非运动症状相关病理过程的潜在作用，为PD非运动症状的综合干预提供新的研究思路。

Non-motor symptoms of Parkinson’s disease (PD) involve multidimensional manifestations such as hyposmia, rapid eye movement sleep behavior disorder, mood disorder, cognitive impairment and autonomic nerve dysfunction, which can occur in the prodromal and progressive stages of the disease. Its occurrence and development are closely related to abnormal folding, aggregation, clearance disorder of alpha-synuclein (α-syn) and prion-like transmission. Ciwujia (Acanthopanacis Senticosi Radix et Rhizoma seu Caulis)has the effects of invigorating qi and spleen, tonifying kidney and tranquilizing mind. Modern pharmacological studies have shown that its multi-components, multi-targets and multi-pathways regulation characteristics are highly compatible with the complexity of the pathological cascade of α-syn. Focusing on the pathological cascade of α-syn, by systematically combing the physiological conformation dynamics of α-syn, the basis of pathological transformation, the driving factors of aggregation, the imbalance of cell homeostasis and the mechanism of central nervous circuit damage, the potential role of Acanthopanacis Senticosi Radix et Rhizoma seu Caulisin indirectly affecting the abnormal accumulation of α-syn and the pathological process related to non-motor symptoms by improving α-syn pathological related microenvironment such as oxidative stress, neuroinflammation, protein clearance disorder, neurotransmitter imbalance and brain-gut axis abnormality was further analyzed, which provided a new research idea for the comprehensive intervention of non-motor symptoms of PD.

R284

黑龙江省自然科学基金项目（PL2024H243）；中国博士后科学基金第73批面上项目（2023M731029）；黑龙江省博士后资助（面上项目）（LBH-Z22251）；黑龙江省大学生创新训练计划项目（202410228025）；黑龙江省2026年度中医药科研课题项目（ZHY2026-025）