绞股蓝Gynostemma pentaphyllum是葫芦科绞股蓝属药食同源植物，药用历史悠久，干燥地上部分为其药用部位。绞股蓝富含皂苷类、黄酮类、多糖类等活性成分，具有调血脂、保肝、辅助肿瘤治疗、改善动脉粥样硬化等广泛的药理作用。系统总结以绞股蓝为主药上市药品的研究现状与进展，围绕其药理作用、基础研究、临床应用及质量标准等展开综述，以期为绞股蓝在临床医学中的推广应用及进一步开发提供理论支持，推动绞股蓝产业向标准化、现代化与国际化发展，为中医药传承创新提供支撑。

Gynostemma pentaphyllum is a medicinal and edible plant belonging to the genus Gynostemma of the family Cucurbitaceae and has a long history of medicinal use. Its dried aerial parts are used medicinally. G. pentaphyllum is rich in various active components such as saponins, flavonoids and polysaccharides, and exhibits a wide range of pharmacological activities, such as lipid-regulating and hepatoprotective effects, adjuvant effects in cancer treatment, and amelioration of atherosclerosis.. This review systematically summarizes the research status and progress of marketed drugs containing G. pentaphyllum as the principal medicinal ingredient, with a focus on their pharmacological effects, basic research, clinical application and quality standards. It aims to provide theoretical support for the popularization, application and further development of G. pentaphyllum in clinical medicine, promote the development of the G. pentaphyllum industry towards standardization, modernization and internationalization, and support the inheritance and innovation of traditional Chinese medicine.

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国家四大慢病重大专项/国家科技创新2030重大项目（2023ZD0506700，2023ZD0506705）；河南省科技创新领军人才项目（254200510041）；河南省中医药科学研究专项（2024ZYZD04）；河南省“三个100”计划-临床研究型医生培养专项“慢性阻塞性肺疾病全周期中医队列研究”（HNCRD202435）