血脑屏障是中枢神经系统药物递送的核心瓶颈。而冰片Borneolum Syntheticum作为传统“引经”药，可通过可逆调节血脑屏障通透性，为脑靶向递送提供独特的天然增效工具。因此，将冰片整合入现代递药系统构建策略，是实现协同增效的有力途径。通过检索CNKI和PubMed数据库2018年以来冰片介导脑部递药系统的相关文献，聚焦该递药系统的构建策略，将其归纳为物理负载、化学偶联与生物融合3类策略，详细阐述了各类策略的设计原理、载体特性及代表性系统，并深入分析构建策略与递药系统稳定性、释放能力、跨血脑屏障与递送能力等关键性能间的影响规律，最终提炼出“治疗需求-策略匹配-工艺评估”的决策原则，为该类系统的设计、性能提升及临床转化提供科学依据与策略参考。

The blood-brain barrier is the core bottleneck for drug delivery to the central nervous system. Bingpian (Borneolum Syntheticum), as a traditional “guide” drug, can reversibly modulate blood-brain barrier permeability, thereby providing a unique natural efficacy-enhancing tool for brain-targeted delivery. Therefore, integrating Borneolum Syntheticum into the construction strategies of modern drug delivery systems is a powerful approach to achieve synergistic enhancement. By retrieving relevant literature on Borneolum Syntheticum-mediated brain-targeted drug delivery systems published since 2018 from CNKI and PubMed databases, focusing on the construction strategies of such drug delivery systems, this study summarized them into three categories: physical loading, chemical conjugation, and biological fusion. The design principles, carrier characteristics, and representative systems of each strategy are elaborated in detail. The influence rules between construction strategies and key properties of drug delivery systems, including stability, release capacity, blood-brain barrier crossing ability, and delivery efficacy, are deeply analyzed. Finally, the core decision-making principle of “treatment needs-strategy matching-process evaluation” is distilled, providing scientific basis and strategic references for the design, performance optimization, and clinical translation of such systems.

R283

国家自然科学基金资助项目（82260771）；江西省“双千计划”创新领军人才长期（青年）项目（jxsq2023101090）；江西省中医药标准化项目（2023A20）；江西省“科技＋中医药”联合计划项目（S2023KJSLG0037）；江西省大学生创新创业训练计划项目（202410412297）