目的 采用文献计量学可视化分析植物外泌体（plant-derived exosomes，PDEs）研究现状及趋势热点，为其基础研究与应用提供理论依据。方法 基于CiteSpace、VOSviewer和Scimago Graphica软件，对中国知网和科学核心集数据库（Web of Science Core Collection，WOSCC）中关于PDEs的中英文文献进行发文趋势、国家分布、发文机构、发文作者、关键词等层面可视化分析，挖掘PDEs的研究热点与前沿进展。结果 共纳入符合要求的文献2 815篇，其中中文文献160篇（5.68%），英文文献2 655篇（94.32%）。PDEs研究领域的主体集中于中国和美国，国际学术关注度逐年提高，年发文量呈现持续上升趋势。研究机构网络分析表明，文献作者间呈明显的区块化分布，国内中国科学院、浙江大学、首都医科大学、南京中医药大学等，国外加利福尼亚大学、伊利诺伊大学等位居机构合作中心。基于高频关键词共现分析表明，当前研究热点聚焦于姜黄、人参、茶叶、枸杞、马齿苋等来源的PDEs在皮肤伤口愈合、神经保护作用、肿瘤治疗、抗炎抗氧化活性及血脑屏障调节等分子机制研究领域。此外，PDEs的提取纯化工艺研究、质量评价标准建立及作为药物递送载体等应用型研究方向也持续被关注。结论 PDEs在神经保护、肿瘤治疗和伤口愈合等方面具有较大的研究和应用潜力，通过对不同植物来源的外泌体提取纯化、开发符合精准医疗需求的新剂型以及探索其适应证将成为PDEs未来的研究趋势。此外，为了深入挖掘PDEs的应用潜力应加强学科交叉协作与新技术应用。

Objective To explore the research status, trends and hotspots of plant-derived exosomes (PDEs) using bibliometric visualization analysis, so as to provide a theoretical basis for their basic research and practical applications. Methods Utilizing CiteSpace, VOSviewer, and Scimago Graphica software, we conducted a comprehensive visualization analysis of Chinese and English literature on PDEs indexed in the China National Knowledge Infrastructure (CNKI) and the Web of Science Core Collection (WOSCC). The analysis encompassed publication trends, geographical distribution, institutional collaboration networks, author contributions, and keyword co-occurrence to identify research frontiers and evolving trajectories in PDEs research. Results A total of 2 815 eligible publications were included in this study, comprising 160 Chinese-language publications (5.68%) and 2 655 English-language publications (94.32%). Research activity in the PDEs field is predominantly concentrated in China and the United States, with global academic attention demonstrating a consistent annual increase. Institutional network analysis revealed distinct modular collaboration patterns, with Chinese institutions—including the Chinese Academy of Sciences, Zhejiang University, Capital Medical University, and Nanjing University of Chinese Medicine—alongside international institutions such as the University of California and the University of Illinois, occupying central positions in collaboration networks. High-frequency keyword co-occurrence analysis identified current research focal points, including PDEs derived from sources such as Jianghuang (Curcumae Longae Rhizoma), Renshen (Ginseng Radix et Rhizoma), tea, Gouqi (Lycii Fructus), and Machixian (Portulacae Herba), with investigations concentrating on molecular mechanisms underlying skin wound healing, neuroprotective effects, oncological therapy, anti-inflammatory and antioxidant activities, and blood-brain barrier modulation. Additionally, sustained research attention is directed toward applied domains including extraction and purification methodologies, establishment of quality evaluation standards, and the development of PDEs as drug delivery vehicles. Conclusion PDEs demonstrate substantial research potential in neuroprotection, oncological therapy, and wound healing applications. Future research trajectories will likely focus on optimizing extraction and purification protocols for PDEs from diverse botanical sources, developing novel formulations tailored to precision medicine requirements, and expanding their therapeutic indications. Furthermore, strengthening interdisciplinary collaboration and integrating emerging technologies will be essential for fully realizing the translational potential of PDEs.

R282.1;G350

中国中医科学院科技创新工程项目（CI2026A04312）；北京市创新新星计划项目（20230484300）；国家自然科学基金项目（82204637）